Environmental & Genetic Influences on Vitamin D Status
The purpose of this study is to determine the effect of environmental and genetic influences on Vitamin D status.
Vitamin D Deficiency
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Environmental & Genetic Influences on Vitamin D Status|
- 25(OH)D levels [ Time Frame: 1 month ] [ Designated as safety issue: No ]25(OH)D levels were measured at the only visit
- Genetic testing of 13 candidate genes [ Time Frame: 1 month ] [ Designated as safety issue: No ]13 candidate genes were tested and their relationship to 25(OH)D examined.
Biospecimen Retention: Samples With DNA
Blood was obtained for genetic testing of selected 13 candidate genes important for vitamin D metabolism
|Study Start Date:||August 2010|
|Study Completion Date:||August 2010|
|Primary Completion Date:||August 2010 (Final data collection date for primary outcome measure)|
Sun exposed people
Sun exposure >3 hours daily for at least 5 days weekly for the last 3 months.
Vitamin D deficiency is a common problem. The principal source of vitamin D for humans is solar exposure, with cutaneous synthesis of vitamin D by photoconversion of 7-dehydrocholesterol in the skin to pre-vitamin D3. Latitude, altitude, season, skin pigmentation, and age are recognized factors that influence how much vitamin D can be made by solar exposure. Surprisingly, Vitamin D deficiency has been described in people dwelling in southern Florida and in surfers in Hawaii. We hypothesize that genetic variations in vitamin metabolism accounts for these differences.
|United States, Nebraska|
|Omaha, Nebraska, United States, 68131|
|Principal Investigator:||Laura Armas, MD||Creighton University|