MiRNAs Evaluate the Prognosis of Sepsis (METPS)
Recruitment status was Recruiting
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||miRNA in the Evaluation of the Value of Sepsis Prognosis Prospective Observational Study|
- all cause mortality [ Time Frame: 28days after admited in ICU ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||July 2010|
|Estimated Study Completion Date:||April 2011|
|Estimated Primary Completion Date:||November 2010 (Final data collection date for primary outcome measure)|
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.
|Contact: Huijuan Wang, master||+86 email@example.com|
|Chinese PLA General Hospital||Recruiting|
|Beijing, Beijing, China, 100853|
|Study Director:||Lixin Xie, Doctor||Pneumology Department of chinese PLA General Hospital|