Eosinophil Markers and Development of Disease in Allergic Rhinitis
Inflammatory proteins from eosinophil granulocytes in blood from patients with seasonal allergic hayfever have been shown to predict development of asthma at a six-year follow-up. This study is a 15-year follow-up of the same patients to verify earlier results and study disease development.
Seasonal Allergic Rhinitis
|Official Title:||Eosinophil Markers and Development of Disease in Allergic Rhinitis. A 15-year Follow-up of Patients With Grass Pollen Induced Hayfever.|
- Asthma morbidity [ Time Frame: Single measurement - May 2010 ] [ Designated as safety issue: No ]Patients are asked whether they have experienced asthmatic symptoms or have been disgnosed with asthma within the latest 15 years
- Rhinitis morbidity [ Time Frame: Single measurement - May 2010 ] [ Designated as safety issue: No ]Patients are asked for current hayfever symptoms
|Study Start Date:||May 2010|
|Study Completion Date:||May 2010|
|Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
The study consists of a single visit at which patients fill in a questionnaire on actual hayfever and asthma symptoms as well as current treatment. Blood samples and nasal lavages are drawn and analysed for eosinophils as well as eosinophil cationic protein and tryptase. Spirometry is performed.
If patients use drugs which can interfere with results, ie. corticosteroids or beta-agonists, biochemistry and/or spirometry are omitted.
|Principal Investigator:||Lars Peter Nielsen, MD||Department of Respiratory Research, Aarhus University Hospital, DK-8000 Aarhus C, Denmark|