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Pressure Support During Chest Wall Compression

This study has been completed.
Sponsor:
Information provided by:
Hospital de Clinicas de Porto Alegre
ClinicalTrials.gov Identifier:
NCT01155648
First received: June 23, 2010
Last updated: July 1, 2010
Last verified: June 2010
History of Changes
  Purpose

The purpose of this study is to compare two physiotherapy techniques: chest wall compression versus chest wall compression plus increase of 10 cmH2O in inspiratory pressure.


Condition Intervention
Respiration, Artificial
Critical Care
 Device: Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest.
Device: Chest wall compression for ten minutes in chest

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Increasing Pressure Support During Chest Wall Compression is Useful During Respiratory Therapy?

Resource links provided by NLM:

MedlinePlus related topics: Critical Care
U.S. FDA Resources

Further study details as provided by Hospital de Clinicas de Porto Alegre:

Primary Outcome Measures:
  • Variation of mucus secretion aspirated. [ Time Frame: Two years ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Hemodynamic and pulmonary parameters. [ Time Frame: Two years ] [ Designated as safety issue: Yes ]
    The hemodynamic and pulmonary parameters were collected: Hart rate (HH), respiratory rate (f), mean arterial pressure (MAP) and peripheral arterial saturation of oxygen (SpO2); peak inspiratory pressure (Ppeak),and Tidal volume (VT) measured in the ventilator, dynamic compliance (Cdyn calculated through the formula VT/ Ppeak - PEEP)


Enrollment: 66
Study Start Date: May 2008
Study Completion Date: May 2010
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: PSV group.
Chest wall compression plus increase of 10 cmH2O of PSV.
 Device: Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest.
Active Comparator: chest wall compression group
Chest wall compression
 Device: Chest wall compression for ten minutes in chest

Detailed Description:
  1. After being placed in the supine position in bed, with head angle elevation at 30°, patients were randomized to:group 1 (G1): chest wall compression for ten minutes in chest or group 2 (G2): chest wall compression plus increase of 10 cmH2O in IP in PSV for ten minutes in chest.
  2. Clinical variables and APACHE II were registered.
  3. Parameters analyzed at the beginning (1) and at the end (2) of the protocol were: variation of peak pressure (ΔPp=Pp2-Pp1),variation of tidal volume (ΔVT =VT2-VT1), variation of dynamic compliance (ΔCdyn= Cdyn2-Cdyn1).
  4. The amount of variation of mucus secretion aspirated (ΔSa= Sa2-Sa1) at the end was also measured
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients on mechanical ventilation over 48 hours
  • With ventilatory drive
  • Hemodynamically stable MAP> 60 mmHg
  • With treatment of respiratory therapy

Exclusion Criteria:

  • Contra indication of increased positive inspiratory pressure
  • Peak pressure in the upper airway > 40 cmH2O
  • Osteoporosis diagnosis
  • Deny to participate in the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01155648

Locations
Brazil
Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
Sponsors and Collaborators
Hospital de Clinicas de Porto Alegre
Investigators
Principal Investigator: Silvia R Vieira, PhD Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre
  More Information

No publications provided by Hospital de Clinicas de Porto Alegre

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre
ClinicalTrials.gov Identifier: NCT01155648     History of Changes
Other Study ID Numbers: 07-504
Study First Received: June 23, 2010
Last Updated: July 1, 2010
Health Authority: Brazil: National Committee of Ethics in Research

Keywords provided by Hospital de Clinicas de Porto Alegre:
Mechanical ventilation
Chest physiotherapy
Chest wall compression

ClinicalTrials.gov processed this record on May 22, 2013