Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy (HE)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT01151475
First received: June 25, 2010
Last updated: June 18, 2012
Last verified: June 2012
  Purpose

We wish to study patients with liver cirrhosis during and 2 weeks after an acute episode of liver coma (hepatic encephalopathy). By means of Positron Emission Tomography we investigate; brain blood flow, brain ammonia uptake and brain oxygen consumption. We hypothesize that blood flow an oxygen consumption is diminished and ammonia uptake increased during an acute episode of hepatic encephalopathy.


Condition
Liver Cirrhosis
Hepatic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of HE

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Enrollment: 10
Study Start Date: August 2010
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients with hepatic encephalopathy

Criteria

Inclusion Criteria:

  • patients with an acute episode of hepatic encephalopathy

Exclusion Criteria:

  • previous stroke
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01151475

Locations
Denmark
Gitte Dam
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

No publications provided

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01151475     History of Changes
Other Study ID Numbers: 24698
Study First Received: June 25, 2010
Last Updated: June 18, 2012
Health Authority: Denmark: Danish Dataprotection Agency

Keywords provided by University of Aarhus:
liver cirrhosis
hepatic encephalopathy
ammonia
cerebral blood flow

Additional relevant MeSH terms:
Hepatic Encephalopathy
Liver Cirrhosis
Fibrosis
Brain Diseases
Liver Failure
Hepatic Insufficiency
Liver Diseases
Digestive System Diseases
Brain Diseases, Metabolic
Central Nervous System Diseases
Nervous System Diseases
Metabolic Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on August 28, 2014