Mothers With a History of Depression and Their 10-14 Year Old Daughters

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
Stanford University
ClinicalTrials.gov Identifier:
NCT01129752
First received: May 21, 2010
Last updated: June 21, 2011
Last verified: June 2011
  Purpose

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. The investigators are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters.


Condition Intervention
Depression
Depressive Disorder, Major
Other: No intervention

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Neural Correlates of Mood and Cognitive Bias in a Population at Risk for Depression: Maternal Cognitive and Emotional Functioning

Resource links provided by NLM:


Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Onset of depression [ Time Frame: 18 months ] [ Designated as safety issue: No ]
    participants are interviewed in an 18-month follow-up session


Biospecimen Retention:   Samples With DNA

All participants are asked to submit saliva samples during their second session using sterile salivette containers in order to assess cortisol levels. There is no risk involved in giving these samples.


Enrollment: 240
Study Start Date: February 2004
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
children at risk for depression
children at familial risk for depression
Other: No intervention
there is no intervention for this study

Detailed Description:

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. We are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters. We use a range of methodologies to evaluate these processes, including self-report measures, information-processing performance, HPA-axis functioning and reactivity, and neural responses to emotional stimuli following exposure to stressful experiences.

  Eligibility

Ages Eligible for Study:   9 Years to 15 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old. Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.

Criteria

Inclusion Criteria:

  • Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old.
  • Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.

Exclusion Criteria:

  • Eligible mothers cannot:

    • currently be in treatment for drug or alcohol abuse
    • have significant symptomatology related to psychopathology outside of depression
    • have a medical history of neurological injury or impairment.
  • Mothers who meet the requirements for inclusion in the control group must not have a history of any Axis I disorder.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01129752

Locations
United States, California
Stanford University Department of Psychology
Stanford, California, United States, 94305
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Ian H Gotlib, PhD Stanford University Department of Psychology
  More Information

No publications provided

Responsible Party: Ian H. Gotlib, Principal Investigator, Stanford University School of Medicine
ClinicalTrials.gov Identifier: NCT01129752     History of Changes
Other Study ID Numbers: SU-03172010-5264, 13058
Study First Received: May 21, 2010
Last Updated: June 21, 2011
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Depression
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on August 26, 2014