Sugar-replacement Sweeteners, Taste Perception, and Blood Sugar Control (ADAYP)
Recruitment status was Active, not recruiting
Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study is to examine wether non caloric sweeteners affects how well the body works to control blood sugar. The study includes detailed blood sugar testing after drinking liquids that may contain sucralose. The investigators hypothesize that drinking liquids with sucralose will effect the amounts of specific appetite-affecting substances naturally produced by the body.
|Study Design:||Endpoint Classification: Pharmacodynamics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Regulation of Incretin Release by Non-nutritive Sweeteners in Humans|
- The effect of sucralose on Glucagon Like Peptide -1 (GLP-1) release [ Time Frame: Baseline ] [ Designated as safety issue: No ]we will measure plasma GLP-1, glucose, C-peptide and insulin concentrations during a 5-hour modified Oral Glucose Tolerance Test (mOGTT) administered 10 minutes after subjects consume sucralose in water or an equal volume of water without sucralose (control condition).
- sucralose taste detection and GLP-1 (glucagon-like peptide - 1) levels [ Time Frame: baseline ] [ Designated as safety issue: No ]A measure of subject's ability to taste sucralose will be correlated with the hormonal response of GLP-1 during a 5-hour modified oral glucose tolerance test.
|Study Start Date:||May 2010|
|Estimated Study Completion Date:||February 2013|
|Primary Completion Date:||April 2012 (Final data collection date for primary outcome measure)|
Dietary Supplement: Sucralose
Please refer to this study by its ClinicalTrials.gov identifier: NCT01128829
|United States, Missouri|
|Washington University School of Medicine|
|St. Louis, Missouri, United States, 63110|
|Principal Investigator:||Marta Y Pepino de Gruev, Ph.D.||Washington University School of Medicine|