Comparison of 1 vs 3 Sets of Resistance Training on Muscular Hypertrophy

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Richard Washburn, University of Kansas
ClinicalTrials.gov Identifier:
NCT01107691
First received: March 26, 2010
Last updated: August 19, 2013
Last verified: August 2013
  Purpose

This study is designed to investigate the effects of two levels of resistance weight training on body composition, energy expenditure, and energy intake in men and women. The weight training will take about one hour to complete. Participants will perform the training 3 days per week for 9 months in a private exercise room equipped with state of the art equipment and a personal trainer to help guide you through the exercises.

The project lasts 21 months total with one follow-up visit 1-year from your last training date. You will be required to stay in the Lawrence area and train 3 day/week over the summer & holidays.


Condition Intervention
Obesity
Other: Amount of resistance offered in training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Resistance Training Energy Balance & Weight Management

Resource links provided by NLM:


Further study details as provided by University of Kansas:

Primary Outcome Measures:
  • Body Composition [ Time Frame: 21 Months ] [ Designated as safety issue: No ]
    Changes in body composition will be evaluated by measuring the change in percent body fat, total fat mass, and total lean mass by dual energy x-ray absorptiometry (DEXA).


Secondary Outcome Measures:
  • Resting Metabolic Rate [ Time Frame: 9 months ] [ Designated as safety issue: No ]
    Resting metabolic rate as measured by indirect calorimetry as kcal/day will be evaluated. Also, substrate oxidation (fat and carbohydrate oxidation) will be evaluated at these time points.

  • Muscular Strength [ Time Frame: 9 months ] [ Designated as safety issue: No ]
    One rep max strength will be measured on the chest and leg press.

  • Daily Energy Expenditure [ Time Frame: 9 months ] [ Designated as safety issue: No ]
    Total daily energy expenditure over a 14 day period will be measured using doubly labeled water.


Estimated Enrollment: 120
Study Start Date: April 2009
Estimated Study Completion Date: March 2014
Estimated Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Resistance training
1 set of progressive resistance training per session
Other: Amount of resistance offered in training
to determine the impact of the volume (1 vs. 3 sets) of a progressive resistance training protocol for inducing muscular hypertrophy
Experimental: 3 sets per session
3 sets of progressive resistance training per session
Other: Amount of resistance offered in training
to determine the impact of the volume (1 vs. 3 sets) of a progressive resistance training protocol for inducing muscular hypertrophy
No Intervention: Control
Non exercise control group

Detailed Description:

We propose to conduct a randomized controlled efficacy trial (RT-1 set vs. RT-3 sets vs. non exercise control) to evaluate the potential for a longer intervention (9 months RT with body composition assessments 1 yr post RT completion) with a higher volume of RT (3 sets) to enhance the effects on body composition and energy expenditure observed in the pilot, and to determine the impact of the 2 levels of RT on free-living energy balance (expenditure by doubly labeled water and intake by digital photography and 24-hr recalls). This investigation will be conducted in a sample of healthy, normal and overweight, sedentary, young adult men and women; a group at high risk for development of overweight and obesity. The specific aims of this project are to determine the impact of the volume (1 vs. 3 sets) of a progressive RT protocol for inducing muscular hypertrophy, as recommended by the American College of Sports Medicine, on body weight and body composition (fat mass, fat-free mass (FFM), % body fat) and energy balance. Our results will provide information relative to the minimum volume of RT that may be associated with body weight/fat gain which may inform the development of guidelines for RT to prevent weight gain or to alter body composition. If RT has a favorable impact on energy balance and body composition, it may provide an attractive alternative to aerobic exercise for weight management for busy young adults, as RT requires minimal time, and no need to change clothes or shower (i.e. minimal or no sweating).

  Eligibility

Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 22-<30
  • 18- 30 years old
  • sedentary
  • no medications
  • weight stable for at least 3 months

Exclusion Criteria:

  • Tobacco/Drug user
  • metabolism altering medication
  • gain/lost 10lbs in the last 3 months
  • current exerciser
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01107691

Locations
United States, Kansas
Energy Balance Lab, The University of Kansas
Lawrence, Kansas, United States, 66045
Sponsors and Collaborators
University of Kansas
Investigators
Principal Investigator: Richard A Washburn, PhD University of Kansas
  More Information

No publications provided

Responsible Party: Richard Washburn, Associate Professor, University of Kansas
ClinicalTrials.gov Identifier: NCT01107691     History of Changes
Other Study ID Numbers: HSCL17623, NIDDKRO180832
Study First Received: March 26, 2010
Last Updated: August 19, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Kansas:
resistance and weight loss training

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on April 16, 2014