Genetics of Obesity in Chinese Youngs (GOCY)
The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs|
Whole blood,fasting serum and morning urine
|Study Start Date:||March 2009|
|Estimated Study Completion Date:||September 2013|
|Estimated Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
Healthy lean control group
BMI:18.5-22.9kg/m2. Age:14-30 years old. To be proved normal by the examinations of liver and kidney function,blood lipids profile,fasting and postprandial plasma glucose, fasting insulin and HbA1c.
obesity group with BMI ≥30
obesity group 1000, lean healthy control group 1000
Obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.Previous studies found that genetic factors determine 40%-70% of obese phenotype.Under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity.
Recent extensive genome-wide association studies(GWASs) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.Two studies in 2010 Nature,for the first time, put rare copy number variation (CNV)in association with severe early-onset obesity.Their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases.
Obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.The present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative PCR,gene chip,construction of viral vectors,transfection,taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.Meanwhile biomarkers and genetic risk factors will be evaluated in the study subjects.
|Contact: Guang Ning, MD.PhD||86-21-64370045 ext firstname.lastname@example.org|
|Contact: Jie Hong, PhD||86-21-64370045 ext email@example.com|
|Shanghai Jiao Tong University School of Medicine||Recruiting|
|Shanghai, Shanghai, China, 200025|
|Contact: Guang Ning, MD.PhD 86-21-64370045 ext 665340 firstname.lastname@example.org|
|Contact: Jie Hong, PhD 86-21-64370045 ext 665345 email@example.com|
|Principal Investigator: Guang Ning, MD.PhD|
|Principal Investigator:||Guang Ning, MD.PhD||Shanghai Jiao Tong University School of Medicine|