Comparison of Lidocaine and Remifentanil for the Effect on Responses to the Endotracheal Tube During Emergence From General Anesthesia

This study has been completed.
Sponsor:
Information provided by:
Yonsei University
ClinicalTrials.gov Identifier:
NCT01082458
First received: March 4, 2010
Last updated: November 18, 2010
Last verified: November 2010
  Purpose

Target concentration infusion(TCI) of remifentanil (2.0ng/ml) suppresses the cough induced by endotracheal tube more effectively than intravenous administration of lidocaine (1.5mg/kg).


Condition Intervention
Thyroidectomy
Drug: remifentanil / lidocaine

Study Type: Interventional
Study Design: Primary Purpose: Prevention
Official Title: Comparison of Lidocaine and Remifentanil for the Effect on Responses to the Endotracheal Tube During Emergence From General Anesthesia

Resource links provided by NLM:


Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • Comparison of lidocaine and remifentanil for the effect on responses to the endotracheal tube during emergence from general anesthesia [ Designated as safety issue: No ]
    The incidence and the grade of cough during emergence from general anensthesia between remifentanil TCI group and lidocaine IV administration group.


Enrollment: 67
Study Start Date: February 2010
Study Completion Date: July 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: remifentanil / lidocaine

    Remifentanil TCI group : target controlled infusion of 2.0ng/ml of remifentanil on end of surgery.

    Lidocaine IV group : Intravenous administration of 1.5mg/kg of lidocaine on end of surgery.

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Females older than 20 years old

Exclusion Criteria:

  • Patients with acute or chronic respiratory disease, hypertension, gastro-esophageal reflux disease, having preoperative sedatives or mucolytics, and current smoker.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01082458

Locations
Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Yonsei University
  More Information

No publications provided

Responsible Party: Jung-Lim Lee / Assistant Professor, Anesthesiology and Pain Medicine
ClinicalTrials.gov Identifier: NCT01082458     History of Changes
Other Study ID Numbers: 4-2009-0519
Study First Received: March 4, 2010
Last Updated: November 18, 2010
Health Authority: Korea: Food and Drug Administration

Keywords provided by Yonsei University:
Patients scheduled to undergo thyroidectomy

Additional relevant MeSH terms:
Anesthetics
Lidocaine
Remifentanil
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Anesthetics, Local
Sensory System Agents
Peripheral Nervous System Agents
Anti-Arrhythmia Agents
Cardiovascular Agents
Voltage-Gated Sodium Channel Blockers
Sodium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Analgesics, Opioid
Narcotics
Analgesics
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General

ClinicalTrials.gov processed this record on August 27, 2014