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Cerebral Antibiotics Distribution After Acute Brain Injury

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2010 by Poitiers University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Poitiers University Hospital
ClinicalTrials.gov Identifier:
NCT01059890
First received: January 29, 2010
Last updated: NA
Last verified: January 2010
History: No changes posted
  Purpose

The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.


Condition Intervention Phase
Bacterial Infection
Brain Injury
 Drug: cefotaxime
Drug: Metronidazole
Drug: Ciprofloxacin
Drug: Fosfocine
 Phase 1

Study Type: Interventional

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Poitiers University Hospital:

Arms Assigned Interventions
Experimental: Cefotaxime Drug: cefotaxime
Experimental: Metrodinazole Drug: Metronidazole
Experimental: Ciprofloxacine Drug: Ciprofloxacin
Experimental: Fosfocine Drug: Fosfocine

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Acute brain injury
  • Patient who receive an antibiotic for an infection or prophylaxy
  • Glasgow coma score < 8

Exclusion Criteria:

  • Age < 18 years old
  • Pregnant woman
  • HCV, HIV, HBV infection
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01059890

Contacts
Contact: Claire DAHYOT, MD 05 49 44 44 44 ext 41369 c.dahyot-fizelier@chu-poitiers.fr

Locations
France
Poitiers University Hospital - 2 rue de la Milétrie - Réanimation chirugicale Recruiting
Poitiers, France, 86021
Contact: Claire DAHYOT, MD     05 49 44 44 44 ext 41369     c.dahyot-fizelier@chu-poitiers.fr    
Sponsors and Collaborators
Poitiers University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01059890     History of Changes
Other Study ID Numbers: A-BRAIN
Study First Received: January 29, 2010
Last Updated: January 29, 2010
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Additional relevant MeSH terms:
Bacterial Infections
Brain Injuries
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Cefotaxime
Cefoxitin
Ciprofloxacin
Metronidazole
 Anti-Bacterial Agents
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Radiation-Sensitizing Agents
Physiological Effects of Drugs
Antiprotozoal Agents
Antiparasitic Agents

ClinicalTrials.gov processed this record on May 21, 2013