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Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans (VINE)

This study has been completed.
Sponsor:
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Bo Fernhall, University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier:
NCT01024634
First received: December 2, 2009
Last updated: December 14, 2012
Last verified: December 2012
History of Changes
  Purpose

The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians.


Condition Intervention
Vascular Health
Autonomic Function
 Behavioral: Endurance Exercise

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Illinois at Urbana-Champaign:

Primary Outcome Measures:
  • Arterial function [ Time Frame: Pre, following a 4 week control period and after 8 weeks of exercise intervention ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Autonomic function [ Time Frame: Pre, following a 4 week control period and following 8 weeeks of an exercise intervention ] [ Designated as safety issue: No ]

Enrollment: 91
Study Start Date: September 2009
Study Completion Date: December 2012
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
African American Group
A group of young African American males and females
 Behavioral: Endurance Exercise
8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session
Caucasian Group
a group of young Caucasian men and women
 Behavioral: Endurance Exercise
8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session

Detailed Description:

African-Americans are at greater risk than Caucasians for developing hypertension, cardiovascular disease, stroke and renal disease. This is likely related to arterial dysfunction including greater arterial stiffness, and reduced microvascular reactivity of resistance arteries in African-Americans. In addition, African-Americans have higher levels of inflammatory markers, and a greater sympathoexcitatory response to various stressors. This imbalance between sympathetic and reduced parasympathetic activation may directly affect vascular function and potentiate a greater inflammatory response, further altering key structural and functional properties of the vascular wall. The overall aim of this proposal is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians. We will examine these effects at rest and following a high intensity (maximal cycle ergometry) sympathoexcitation at both pre- and post-intervention time points, since sympathoexcitation may elucidate changes not evident at rest. Because African-Americans have higher levels of arterial stiffness, lower microvascular reactivity, greater responses to sympathoexcitation, greater levels of inflammatory markers and greater vasoconstrictive tone, we hypothesize that African-Americans will show differential responses to exercise training and benefit more compared to a matched group of Caucasians.

  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Subjects in good health with no cardiovascular, metabolic, or inflammatory disease, who do not use cardiovascular medications or antioxidant vitamin supplementation, including use of anti-inflammatory (including aspirin) or steroidal substances in the past 2 months will be inlcuded

Exclusion Criteria:

  • Subjects who smoke, are severely obese (body mass index > 35 kg/m2), or who have hypertension (blood pressure >140/90mmHg), diabetes (fasting glucose >110mg/dl), hyperlipidemia, inflammatory disease (rheumatoid arthritis and systemic lupus erythematosus, etc) or diagnosed cardiovascular disease including, coronary heart disease, hypertension and cardiac arrhythmia or renal disease, will be excluded
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01024634

Locations
United States, Illinois
Kinesiology and Community Health Department, University of Illinois at Urbana-Champaign
Urbana, Illinois, United States, 61801
Sponsors and Collaborators
University of Illinois at Urbana-Champaign
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: Bo Fernhall, Ph.D. University of Illinois at Urbana-Champaign
  More Information

No publications provided

Responsible Party: Bo Fernhall, Professor, University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier: NCT01024634     History of Changes
Other Study ID Numbers: UIUC 09599, 1R01HL093249-01A1
Study First Received: December 2, 2009
Last Updated: December 14, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of Illinois at Urbana-Champaign:
Arterial stiffness
Endothelial function
Autonomic function
Inflammation

ClinicalTrials.gov processed this record on May 21, 2013