Correlation of Genetic Polymorphism and Livedo Vasculitis

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00975871
First received: September 11, 2009
Last updated: October 21, 2009
Last verified: October 2009
  Purpose

Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.


Condition
Livedo Vasculitis
Livedoid Vasculitis
Livedoid Vasculopathy
Genetic Pleomorphism
Leiden Mutation

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Correlation of Genetic Polymorphism and Livedo Vasculitis

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA

Buccal mucosa cotton tip swab


Enrollment: 50
Study Start Date: October 2007
Study Completion Date: April 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
Detailed Description:

Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet. This chronic disease is characterized by healed white, atrophic scars named atrophie blanche. The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls. It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. This study is trying to find the correlation between Taiwanese patients and these four genes.

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

General population

Criteria

Inclusion Criteria:

  • Clinical diagnosis of livedo vasculitis

Exclusion Criteria:

  • No special exclusion criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00975871

Locations
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Tsen-Fang Tsai, MD National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: Tsen-Fang Tsai/M.D, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00975871     History of Changes
Other Study ID Numbers: 0961172000
Study First Received: September 11, 2009
Last Updated: October 21, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Livedo vasculitis
Genetic pleomorphism

Additional relevant MeSH terms:
Livedo Reticularis
Vascular Diseases
Vasculitis
Cardiovascular Diseases
Peripheral Vascular Diseases
Signs and Symptoms
Skin Diseases
Skin Diseases, Vascular
Skin Manifestations

ClinicalTrials.gov processed this record on October 21, 2014