Smoking Cessation Effect of Tea Filter Through Inhibition of Nicotine Receptor
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Purpose
Cigarette smoking is the major risk factor for a series of life threatening diseases including cancer and heart attack, which causes millions of deaths each year worldwide. Many of the harmful effects of cigarette smoking can be reversed by quitting; however, due to the addictive nature of nicotine, quitting smoking is extremely difficult. Despite the efforts, currently available methods produce only modest smoking cessation rates with relapse. Previously, tea components were shown to protect effect against cigarette smoke-induced toxicity. Here the investigator reported an unprecedented smoking cessation effect of tea. Green tea was made into cigarette filters and tested for its smoking cessation effect in a double-blind clinical study. The tea filter could effectively achieve abstinence relapse using smoking process to quite smoking and easy to be used by smoker without any side effects and psychological obstacles. This work provides a new idea and innovative method to combat tobacco epidemic. Its implementation and popularization may make a great contribution towards to reducing the smoking-related diseases, and relieving the public health burden and pollution caused by cigarette smoking.
| Condition |
|---|
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Tobacco Cessation |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control |
| Official Title: | Phase 1 Study on Smoking Cessation Effect of Tea Filter |
- number of cigarettes consumed daily by every volunteer smoker [ Time Frame: 1-5 months ] [ Designated as safety issue: Yes ]
- exhaled carbon monoxide by the volunteers [ Time Frame: in the evening ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples Without DNA
CO
| Enrollment: | 159 |
| Study Start Date: | January 2009 |
| Study Completion Date: | July 2009 |
| Primary Completion Date: | May 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
lifestyle
70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters).
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tea filter
The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.
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Show Detailed Description
Eligibility| Ages Eligible for Study: | 18 Years to 65 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters).
The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.
Inclusion Criteria:
- Healthy male cigarette smokers, aged 18 to 65 years
Exclusion Criteria:
- Exclusion criteria included treatment with an investigational drug within the previous month
- Major depression within the prior year
- Panic disorder
- Psychosis
- Bipolar disorder
- Use of nicotine replacement therapy or other drugs within the previous 3 months
- Cardiovascular disease
- Clinically significant medical disease
- Drug or alcohol abuse or dependence within the past year
- Use of tobacco products other than cigarette smoking within the previous month.
Contacts and Locations| China | |
| Ran Tao | |
| Beijing, China, 100700 | |
| Study Director: | Ran Tao, MD | Addiction Branch, Beijing Military Reneral Hospital |
More Information
No publications provided
| Responsible Party: | Ran Tao/, Beijing Military Region General Hospital |
| ClinicalTrials.gov Identifier: | NCT00971529 History of Changes |
| Other Study ID Numbers: | zhaotaoliang123 |
| Study First Received: | August 20, 2009 |
| Last Updated: | September 3, 2009 |
| Health Authority: | China: The Department of Health, The General Logistics Department of Beijing Military Region |
Keywords provided by General Hospital of Beijing PLA Military Region:
|
Smoking cessation tea filter |
Additional relevant MeSH terms:
|
Smoking Habits |
ClinicalTrials.gov processed this record on June 18, 2013