Inclusion Criteria:

• Healthy as determined by a responsible physician, based on a medical evaluation including medical history, physical examination, laboratory tests and cardiac monitoring.
• Subjects are not poor metabolizers based on genotyping for the major CYP2C9, 2C19, 2D6 alleles
• Male or female between 20 and 50 years of age at the time of screening, inclusive.
• A female subject is eligible to participate if she is of Non-childbearing potential or postmenopausal
• Body weight greater than or equal to 45 kg and BMI within the range 18.5 to 24.9 kg/m2 (inclusive).
• QTc < 450 msec
• Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
• Able to understand and comply with protocol requirements, instructions and protocol-stated restrictions.

Exclusion Criteria:

• As a result of the medical interview, physical examination, or screening investigations, the Investigator considers the subject unfit for the study.
• Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements within 7 days (14 days if the drug is a potential enzyme inducer, such as Panaz ginseng, Gingko biloba or St. John's Wort [Hypericum perforatum]) or 5 half-lives (whichever is longer) prior to the first dose of study medication in each Part of the study and during each active part of the study (e.g., Part 1 and Part 2), unless in the opinion of the Investigator and sponsor the medication will not interfere with the study procedures or compromise subject safety. Herbal medications include, but are not limited to: traditional Chinese, Korean and Japanese medicines, Panaz ginseng, Gingko biloba or St John's wort (Hypericum perforatum) or any Traditional Chinese herbal medicines (TCM) South Asian Ayurvedic medicine, Traditional Korean Medicines and Japanese Kampo.
• Use of caffeine- or theobromine-containing beverages (e.g., coffee, tea, certain colas, green tea and oolong tea, Yerba Mate, Guarana, and South American cocoa) and foods (e.g., chocolate), or alcohol-containing beverages within 72 hours prior to dosing in each Part of the study and during each active part of the study (e.g., Part 1 and Part 2).
• Consumption of the following foods or drinks within 72 hrs prior to dosing in each Part of the study and during each active part of the study (e.g., Part 1 and Part 2): red wine, Seville oranges, grapefruits, pommelos, cruciferous vegetables (e.g., broccoli, Brussels sprouts, cabbage, celery), char-grilled meats, grapefruit juice.
• The subject has a positive pre-study drug/alcohol screen. A minimum list of drugs that will be screened for include amphetamines, barbiturates, cocaine, opiates, cannabinoids and benzodiazepines.
• Urinary cotinine levels indicative of current smoking or history of regular use of tobacco- or nicotine-containing products within two months prior to screening. This includes chewing tobacco, Gutka, hand-rolled tobacco cigarettes, Biddis, cigars, and Snuff.
• A positive Hepatitis B surface antigen or positive Hepatitis C antibody at screening.
• A positive test for HIV antibody
• History of regular alcohol consumption within 6 months of the study
• The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, five half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
• Systolic blood pressure outside the range of 80 to 140 mmHg, without antihypertensive therapy and no history of hypertension or diastolic blood pressure outside the range of 60 to 85 mmHg, or heart rate outside the range of 50 to 100 beats per minute (bpm) for female and 45 to 100 beats per minute (bpm) for male subjects. Blood pressure and heart rate should be taken after 10 minutes of rest.
• History of syncope or vaso-vagal attacks.
• Pre-existing condition interfering with normal gastrointestinal anatomy or motility, hepatic or renal function, that could interfere with the absorption, metabolism, or excretion of the study drugs.
• Exposure to more than four new chemical entities within 12 months prior to the first dosing day.
• Has a known intolerance or hypersensitivity to aspirin, NSAIDS, or benzodiazepines, or a known intolerance to the active and/or inactive ingredients in omeprazole, dextromethorphan, caffeine, rosiglitazone, midazolam, rosuvastatin, flurbiprofen, ketoconazole, fluconazole, rifampin, quinidine, gemfibrozil, and fluvoxamine.
• Has any condition or symptom contraindicated for administration of the probe compounds or inhibitors as follows: omeprazole (hypersensitivity, gastric ulcer with possible malignant tumor), dextromethorphan (hypersensitivity to dextromethorphan, co-administration with monoamine oxidase inhibitors), caffeine (hypersensitivity to caffeine), rosiglitazone (heart disease, edema), midazolam (narrow angle glaucoma), rosuvastatin (liver disease, LFT elevations), flurbiprofen (digestant ulcer), ketoconazole (LFT elevations), fluconazole (LFT elevations), rifampin (porphyria, LFT elevations), quinidine (heart conduction abnormalities - e.g., A-V block; junctional rhythm), gemfibrozil (hepatic dysfunction, renal dysfunction, gallbladder disease) and fluvoxamine (use of monoamine oxidase (MAO) inhibitors within 14 days of fluvoxamine administration). The Investigator should also reference the product information of each drug administered in the study.
• History of sensitivity to heparin or heparin-induced thrombocytopenia (if heparin is used to maintain the patency of an intravenous cannula).
• Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
• EGG abnormalities
• Pregnant females or lactating females.