Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Medical University of Graz
ClinicalTrials.gov Identifier:
NCT00942786
First received: July 18, 2009
Last updated: November 20, 2013
Last verified: November 2013
  Purpose

The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.


Condition
3 Years Cardiac Morbidity and Mortality

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome

Further study details as provided by Medical University of Graz:

Primary Outcome Measures:
  • Major adverse cardiac event [ Time Frame: in-hospital and during 3 years follow-up ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples Without DNA

one vial of serum per patient is retained


Enrollment: 302
Study Start Date: February 2008
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
No treatment
Consecutive patients undergoing emergency surgery

Detailed Description:

The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Consecutive patients undergoing emergency non-cardiac surgery

Criteria

Inclusion criteria:

  • Emergency surgery:

    1. Vascular
    2. Intra-abdominal
    3. Orthopedic

      Exclusion Criteria:

  • Patients unable to provide informed consent
  • Thoracic surgery
  • Trauma surgery
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00942786

Locations
Austria
Department of Anesthesia and Intensive Care Medicine
Graz, Austria, 8036
Sponsors and Collaborators
Medical University of Graz
Investigators
Principal Investigator: Elisabeth Mahla, M.D. Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz
  More Information

No publications provided

Responsible Party: Medical University of Graz
ClinicalTrials.gov Identifier: NCT00942786     History of Changes
Other Study ID Numbers: 19-077 ex 07/08
Study First Received: July 18, 2009
Last Updated: November 20, 2013
Health Authority: Austria: Ethikkommission

Keywords provided by Medical University of Graz:
natriuretic peptides
emergency non-cardiac surgery

Additional relevant MeSH terms:
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on August 26, 2014