Single Dose Safety Study for Compound to Treat Anemia in Patients With Renal Impairment

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT00935831
First received: July 7, 2009
Last updated: April 12, 2012
Last verified: April 2012
  Purpose

The purpose of this study is to characterize the safety and tolerability of single doses of compound 1278863A in subjects with renal impairment.


Condition Intervention Phase
Healthy
Renal Impairment
Drug: 1278863
Drug: Placebo
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacokinetics/Dynamics Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: A Phase I, Single-Dose, Randomized and Single-Blind (Part 1), Fixed Sequence and Open-Label (Part 2), Studyto Evaluate the Safety, Pharmacokinetics, andPharmacodynamics of 1278863A in Subjects With RenalImpairment and Matched Healthy Volunteers

Resource links provided by NLM:


Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • AUC (0-24), Cmax, tmax and half-life [ Time Frame: Parts 1&2: Days 1-3 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Adverse Events reporting [ Time Frame: throughout study ] [ Designated as safety issue: Yes ]
  • Safety Labs (Chemistry) [ Time Frame: Screening, Day -1, 2, 3 ] [ Designated as safety issue: Yes ]
  • Safety Labs (Hematology) [ Time Frame: Screening, Days -1, 2, 3 ] [ Designated as safety issue: Yes ]
  • Safety Labs (Urinalysis) [ Time Frame: Screening, Days -1, 2, 3 ] [ Designated as safety issue: Yes ]
  • Vital Signs (blood pressure and heart rate) [ Time Frame: Screening, Days 1, 2, 3 ] [ Designated as safety issue: Yes ]
  • 12-lead ECG [ Time Frame: Screening, Day 1 ] [ Designated as safety issue: Yes ]
  • Clinical Monitoring/Observation [ Time Frame: throughout ] [ Designated as safety issue: Yes ]
  • Actual values, rate of rise, rate of decline and maximum change from baseline in erythropoietin [ Time Frame: Days 1, 2, 3 ] [ Designated as safety issue: No ]
  • Actual values, rate of rise, rate of decline and maximum change from baseline in VEGF [ Time Frame: Days 1, 2 ] [ Designated as safety issue: No ]
  • Actual values, rate of rise, rate of decline and maximum change from baseline in Hepcidin [ Time Frame: Days 1, 2 ] [ Designated as safety issue: No ]
  • Actual values, rate of rise, rate of decline and maximum change from baseline in TIBC (total iron binding capacity) [ Time Frame: Screening, Days 1, 3 ] [ Designated as safety issue: No ]

Enrollment: 12
Study Start Date: August 2009
Study Completion Date: April 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Active drug Drug: 1278863
50mg, 150mg
Placebo Comparator: Placebo Drug: Placebo
matching placebo

Detailed Description:

Compound 1278863A is a novel small molecule agent, which stimulates erythropoiesis through inhibition of hypoxia-inducible factor (HIF)-prolyl hydroxylases (EGLNs). This compound is being developed for the treatment of anemia. This study, PHI112843, will be the first administration of 1278863A to investigate the safety, tolerability, pharmacokinetics and/or pharmacodynamics of single oral doses of 50 mg and 150 mg in pre-dialysis subjects with moderate or severe renal impairment and 150 mg in hemodialysis-dependent subjects. Four to eight subjects will complete each dose cohort. Multiple blood samples for pharmacokinetic and/or pharmacodynamic analyses will be obtained post-dose in each cohort. Safety will be assessed by measurement of vital signs, cardiac monitoring, collection of adverse event assessments and laboratory safety tests.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. A male or female is eligible to enroll and participate in this study if he/she:

    • (Part 1) has Moderate to Severe Renal Impairment (equivalent to NKF KDOQI Stage 3 or 4, not receiving dialysis) as determined by estimated Glomerular Filtration Rate (eGFR) calculated by the abbreviated MDRD equation, OR has Normal Renal Function determined by creatinine clearance (CLCR) via the Cockcroft-Gault equation, using serum creatinine and demographic data, obtained at Screening. Subjects with Normal Renal Function should have no greater than trace blood or protein on Screening urinalysis.
    • (Part 2) has severe renal impairment (end-stage renal failure) and has been on stable hemodialysis treatment (three times weekly) for 3 months prior to Screening.
    • otherwise healthy or considered clinically stable with respect to underlying renal impairment as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, laboratory tests and cardiac monitoring.
    • has clinical laboratory test results that are considered clinically stable in the opinion of the Principal Investigator, especially if the clinical abnormality or laboratory parameter is deemed associated with the subject's underlying renal impairment. A normal subject with a clinical abnormality or laboratory parameters outside the reference range may be included only if the Investigator and the Medical Monitor agree that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures.
  2. Male or female between 18 and 65 years of age inclusive, at the time of signing the informed consent.
  3. A female subject is eligible to participate if she is of:

    - Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MlU/ml and estradiol < 40 pg/ml (<140 pmol/L) is confirmatory]. Females on hormone replacement therapy (HRT) and whose menopausal status is in doubt will be required to use one of the contraception methods described in the protocol if they wish to continue their HRT during the study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal status prior to study enrollment. For most forms of HRT, at least 2-4 weeks will elapse between the cessation of therapy and the blood draw; this interval depends on the type and dosage of HRT.

    Following confirmation of their post-menopausal status, they can resume use of HRT during the study without use of a contraceptive method.

  4. Male subjects must agree to use one of the contraception methods listed in the protocol. This criterion must be followed from the time of the first dose of study drug until completion of the Follow-up visit.
  5. Body weight greater than or equal to 50 kg and BMI within the range 17 - 33 kg/m2 (inclusive).
  6. AST, ALT, alkaline phosphatase and bilirubin less than or equal to 1.5xULN (isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).
  7. QTcB or QTcF < 450 msec; or QTc < 480 msec in subjects with Bundle Branch Block. These can be based on single ECG value or average of triplicate values obtained over brief recording period.
  8. Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.

Exclusion Criteria:

  1. A hemoglobin value at Screening is:

    • Healthy male subjects or post-menopausal females: > 16.5 g/dL
    • Healthy female subjects: > 15.5 g/dL
    • Renally impaired male or female subjects: <10 g/dL
  2. The values of hematological parameters at Screening, for healthy subjects only, are outside the reference range and clinically significant deemed by the Investigator and Medical Monitor
  3. The values of the following tests at Screening, for healthy subjects only, are:

    • TIBC: outside the reference range
    • Serum iron: outside the reference range
    • Serum ferritin: outside the reference range
  4. Clinically significant abnormal CPK determined by the Investigator and Medical Monitor.
  5. A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of Screening.
  6. A positive test for HIV antibody.
  7. A positive pre-study drug/alcohol screen. A minimum list of drugs that will be screened for include amphetamines, barbiturates, cocaine, opiates, cannabinoids and benzodiazepines. A positive pre-study drug screen, for medications that are prescribed to a subject for pre-existing condition(s), may be allowed if in the opinion of the Investigator and Medical Monitor the medication will not interfere with the study procedures or compromise subject safety.
  8. History of drug abuse or dependence within 6 months of the study.
  9. History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of >21 units for males or >14 units for females. One unit is equivalent to 8 g of alcohol: a half-pint (~240 ml) of beer, 1 glass (125 ml) of wine or 1 (25 ml) measure of spirits.
  10. History of regular use of tobacco- or nicotine-containing in excess of 10 cigarettes per day or equivalent and an inability to abstain from tobacco or nicotine use from admission to the clinical research unit until discharge for each dosing period.
  11. Use of prescription medication known to be inhibitors of BCRP.
  12. Use of non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study drug, unless in the opinion of the Investigator and Medical Monitor the medication will not interfere with the study procedures or compromise subject safety.
  13. History of sensitivity to any of the study drugs, or components thereof or a history of drug or other allergy that, in the opinion of the Investigator or Medical Monitor, contraindicates their participation.
  14. History of sensitivity to heparin or heparin-induced thrombocytopenia. (if the clinical research unit uses heparin to maintain intravenous cannula patency)
  15. Subjects with a pre-existing condition interfering with normal gastrointestinal anatomy or motility, and/or hepatic function that could interfere with the absorption, metabolism, and/or excretion of the study drugs. Examples of conditions that could interfere with normal gastrointestinal anatomy or motility include cholecystectomy, gastrointestinal bypass surgery, partial or total gastrectomy, small bowel resection, vagotomy, malabsorption, Crohn's disease, ulcerative colitis, or celiac sprue. Examples of conditions that could interfere with hepatic function include Gilberts syndrome.
  16. History of peptic ulcer disease.
  17. Subjects with polycystic kidney disease.
  18. Post-renal transplantation subjects.
  19. History of malignancy tumor. Non-melanoma skin cancer that has been definitely removed is allowed.
  20. Pregnant females as determined by positive serum Beta-hCG test at Screening or prior to dosing.
  21. Lactating females.
  22. Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
  23. Unwillingness or inability to follow the procedures, or lifestyle and/or dietary restrictions outlined in the protocol.
  24. Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices of the prohibited fruits from 7 days prior to the first dose of study drug in Dosing Period 1 until the collection of the final pharmacokinetic blood sample in Dosing Period 2, unless in the opinion of the Investigator and Medical Monitor this will not interfere with the study procedures or compromise subject safety.
  25. The subject has participated in a clinical trial and has received an experimental investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
  26. Exposure to more than four experimental investigational products within 12 months prior to the first dosing day.
  27. Subject is mentally or legally incapacitated.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00935831

Locations
New Zealand
GSK Investigational Site
Christchurch, New Zealand, 8011
Sponsors and Collaborators
GlaxoSmithKline
Investigators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

No publications provided

Responsible Party: GlaxoSmithKline
ClinicalTrials.gov Identifier: NCT00935831     History of Changes
Other Study ID Numbers: 112843, PHI112843
Study First Received: July 7, 2009
Last Updated: April 12, 2012
Health Authority: New Zealand: Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

Keywords provided by GlaxoSmithKline:
Tolerability
Safety
Pharmacokinetics
Pharmacodynamics

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on July 29, 2014