Incidence of Postthoracotomy Pain Following General Anesthesia: A Comparison Between TIVA and Inhalation Anesthesia
Recruitment status was Active, not recruiting
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Purpose
The purpose of this study is to evaluate the incidence of postthoracotomy pain between total intravenous anesthesia (TIVA)and inhalation anesthesia after lung surgery.
| Condition | Intervention |
|---|---|
|
Lung Cancer Neoplasms, Lung |
Drug: propofol, remifentanil, sevoflurane |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Incidence of Postthoracotomy Pain Following General Anesthesia: A Comparison Between TIVA and Inhalation Anesthesia |
- Incidence of pain [ Time Frame: 3 and 6 months later after operation ] [ Designated as safety issue: No ]
- pain characters [ Time Frame: 3 and 6 months later after operation ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 400 |
| Study Start Date: | October 2007 |
| Estimated Study Completion Date: | September 2009 |
| Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Group I, Group II
Group I: anesthetized with TIVA (Propofol + Remifentanil) Group II: anesthetized with inhalation (sevoflurane) |
Drug: propofol, remifentanil, sevoflurane
Propofol: using target controlled infusion (TCI); 1-3ug/ml remifentanil: using TCI by 5-20 ng/ml sevoflurane: 2-3volume% (1-2 MAC)
Other Names:
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Detailed Description:
Thoracotomy is one of the most painful surgical incisions. It has been shown that 5-80% of patients still suffer from thoracic pain 2-3 months after surgery and the international association for the study of pain (IASP) defines postthoracotomy pain syndrome (PTTS)as pain that recurs or persists at least 2 months after surgical procedure. Previous reports have shown that the incidence of PTTS varies according to preoperative pain, pain intensity, sex, and types of procedure. However, little is known about the effect of the type of anesthesia to postthoracotomy pain.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
patients scheduled to undergo elective thoracotomy of lung surgery
Inclusion Criteria:
- patients undergo elective thoracotomy of lung surgery
Exclusion Criteria:
- emergency operation age under 18 years patients with unstable hemodynamics
Contacts and Locations| Korea, Republic of | |
| Department of Anesthesiology and Pain Medicine, University of Ulsan College of Medicine, Asan Medical Center | |
| Seoul, Korea, Republic of, 138-736 | |
| Study Chair: | In Cheol Choi, MD, PhD | Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine |
More Information
Publications:
| Responsible Party: | In Cheol Choi, Asan Medical Center |
| ClinicalTrials.gov Identifier: | NCT00935571 History of Changes |
| Other Study ID Numbers: | 20090708 |
| Study First Received: | July 8, 2009 |
| Last Updated: | July 8, 2009 |
| Health Authority: | Korea: Food and Drug Administration Korea: Ministry for Health, Welfare and Family Affairs |
Additional relevant MeSH terms:
|
Neoplasms Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Lung Diseases Respiratory Tract Diseases Anesthetics Propofol Sevoflurane Remifentanil Central Nervous System Depressants Physiological Effects of Drugs |
Pharmacologic Actions Central Nervous System Agents Therapeutic Uses Anesthetics, Intravenous Anesthetics, General Hypnotics and Sedatives Platelet Aggregation Inhibitors Hematologic Agents Anesthetics, Inhalation Analgesics, Opioid Analgesics Sensory System Agents Peripheral Nervous System Agents |
ClinicalTrials.gov processed this record on May 22, 2013