Examining Hair to Determine Tenofovir Exposure

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2009 by National Institute of Mental Health (NIMH).
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:
NCT00903084
First received: May 13, 2009
Last updated: June 25, 2009
Last verified: June 2009
  Purpose

This study will determine whether a hair test can reveal how much of the anti-HIV medication tenofovir a person without HIV has been exposed to.


Condition Intervention Phase
HIV
Drug: Tenofovir Disoproxil Fumarate
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: A Phase 1 Pharmacokinetic Study of Varying Dosing Patterns on Tenofovir Concentrations in Hair

Resource links provided by NLM:


Further study details as provided by National Institute of Mental Health (NIMH):

Primary Outcome Measures:
  • Tenofovir hair concentration under each dosing condition [ Time Frame: Measured 6 weeks after starting each dosing condition ] [ Designated as safety issue: No ]

Estimated Enrollment: 24
Study Start Date: June 2009
Estimated Study Completion Date: June 2010
Estimated Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Participants will receive 7 doses per week, then 4 doses per week, then 2 doses per week (each for 6 weeks) of tenofovir, with a break in between dosing periods.
Drug: Tenofovir Disoproxil Fumarate
300-mg tablet
Other Names:
  • Viread
  • Tenofovir
Active Comparator: 2
Participants will receive 7 doses per week, then 2 doses per week, then 4 doses per week (each for 6 weeks) of tenofovir, with a break in between dosing periods.
Drug: Tenofovir Disoproxil Fumarate
300-mg tablet
Other Names:
  • Viread
  • Tenofovir
Active Comparator: 3
Participants will receive 4 doses per week, then 7 doses per week, then 2 doses per week (each for 6 weeks) of tenofovir, with a break in between dosing periods.
Drug: Tenofovir Disoproxil Fumarate
300-mg tablet
Other Names:
  • Viread
  • Tenofovir
Active Comparator: 4
Participants will receive 4 doses per week, then 2 doses per week, then 7 doses per week (each for 6 weeks) of tenofovir, with a break in between dosing periods.
Drug: Tenofovir Disoproxil Fumarate
300-mg tablet
Other Names:
  • Viread
  • Tenofovir
Active Comparator: 5
Participants will receive 2 doses per week, then 7 doses per week, then 4 doses per week (each for 6 weeks) of tenofovir, with a break in between dosing periods.
Drug: Tenofovir Disoproxil Fumarate
300-mg tablet
Other Names:
  • Viread
  • Tenofovir
Active Comparator: 6
Participants will receive 2 doses per week, then 4 doses per week, then 7 doses per week (each for 6 weeks) of tenofovir, with a break in between dosing periods.
Drug: Tenofovir Disoproxil Fumarate
300-mg tablet
Other Names:
  • Viread
  • Tenofovir

Detailed Description:

Pre-exposure prophylaxis (PrEP) is a new strategy for the prevention of HIV infection. It involves providing antiretroviral medications—those that treat HIV infections—to people before they are exposed to HIV. In clinical trials of PrEP, several of which are currently under way, accurate measurements are needed of how much exposure participants have to the PrEP medications. Current methods, such as self-reports of medication adherence or pill counting, can lead to inaccurate readings of PrEP exposure because participants may forget to take pills and individual differences may affect levels of exposure. Measuring PrEP exposure levels in hair yields an objective marker of exposure that is not subject to self-report errors and that takes into account individual differences. This study will test the use of a hair sample for assessing the level of exposure to tenofovir disoproxil fumarate (TDF), an antiretroviral medication, in people not infected with HIV.

Participation in this study will last 9 months. Participants will undergo baseline testing and then will be randomly assigned to begin one of three conditions, based on dosing schedule: receiving TDF 2, 4, or 7 days per week. All participants will complete each of these dosing schedules, but the order in which they are completed will be randomly assigned. Each dosing schedule will last 6 weeks, with a break of several weeks between them. During each dosing schedule, study staff will confirm that participants are taking each scheduled dose by watching them take the pills on weekdays and calling them on weekends. Follow-up visits will occur at Days 1, 21, and 42 of each dosing schedule. During the baseline and follow-up visits, the following will be completed: an HIV rapid test; counseling about HIV prevention; a brief physical exam; a talk with a staff member about health, symptoms, and other medications; a blood draw, which will be used for several tests; collection of a urine sample and pregnancy test; and optional donation of a sample of pubic hair. On the last day of each dosing schedule, a small sample of hair will be cut from each participant's scalp. An additional follow-up visit will occur after participants complete 4 weeks of the 7-day dosing schedule. This visit will last 24 hours and will involve collection of additional blood samples.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Ability to speak English
  • HIV-1 uninfected, based on HIV rapid testing performed during screening and enrollment
  • Calculated creatinine clearance greater than or equal to 60 mL/min by the Cockcroft-Gault creatinine clearance formula
  • Serum creatinine less than or equal to the site laboratory upper limit of normal
  • Urine dipstick with negative or trace result for both glucose and protein
  • Negative urine beta human chorionic gonadotropin (beta-HCG) test for women
  • Adequate hepatic function, defined as total bilirubin and hepatic transaminases (ALT and AST) less than or equal to twice the upper limit of normal
  • Adequate hematologic function, defined as an absolute neutrophil count greater than or equal to 1,500/mm3, platelet count greater than or equal to 100,000/mm3, and hemoglobin greater than or equal to 10 g/dL
  • Ability to participate in modified directly observed dosing of study drug
  • Ability to provide a personal cell phone number to be contacted on for unobserved modified directly observed therapy (mDOT) visits
  • Minimum length of 3 cm scalp hair in occipital region
  • Willing to provide hair and plasma samples as specified by the protocol
  • Dark hair (brown or black), as assessed by the study clinician
  • Volunteers born female must agree to consistently use effective contraception from at least 21 days prior to enrollment through the last protocol visit for sexual activity that could lead to pregnancy and agree not to seek pregnancy through alternative methods, such as artificial insemination or in vitro fertilization until after the last scheduled protocol visit.

Exclusion Criteria:

  • Active and serious medical problems, including heart or lung disease, diabetes requiring hypoglycemia medications, previously diagnosed malignancies expected to require further treatment, and serious infections
  • Hepatitis B surface antigen positivity
  • History of chronic kidney disease
  • Known osteoporosis, osteomalacia, or osteopenia
  • History of pathological bone fractures not related to trauma
  • Receiving ongoing therapy with any of the following: antiretroviral therapy, interferon or interleukin therapy, aminoglycoside antibiotics, amphotericin B, cidofovir, systemic chemotherapeutic agents, other agents with significant nephrotoxic potential, other agents that may inhibit or compete for elimination via active renal tubular secretion (e.g., probenecid), or other investigational agents
  • Evidence of a gastrointestinal malabsorption syndrome or chronic nausea or vomiting that may confer an inability to receive an orally administered medication
  • Use of hair dyes or hair permanent products in the last 3 months (streaking is acceptable)
  • Current participation in any other research study involving drugs, investigational agents, or medical devices
  • Breastfeeding at screening or enrollment, per participant report
  • Active alcohol or drug use considered sufficient by clinician to hinder compliance with study procedures
  • Elevated risk of HIV infection, as defined in the study protocol
  • At enrollment, has any social or medical condition that, in the investigator's opinion, would preclude provision of informed consent, make participation in the study unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00903084

Contacts
Contact: Albert Liu, MD, MPH 415-554-9104 albert.liu@sfdph.org

Locations
United States, California
University of California, San Francisco Not yet recruiting
San Francisco, California, United States, 94122
Principal Investigator: Albert Liu, MD, MPH         
San Francisco Department of Public Health Not yet recruiting
San Francisco, California, United States, 94102
Principal Investigator: Albert Liu, MD, MPH         
Sponsors and Collaborators
Investigators
Study Chair: Albert Liu, MD, MPH San Francisco Department of Public Health
  More Information

Additional Information:
Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Albert Liu, MD, MPH, San Francisco Department of Public Health
ClinicalTrials.gov Identifier: NCT00903084     History of Changes
Other Study ID Numbers: R21 MH085598, DAHBR 9A-ASPQ
Study First Received: May 13, 2009
Last Updated: June 25, 2009
Health Authority: United States: Federal Government

Keywords provided by National Institute of Mental Health (NIMH):
Pharmacokinetics in Hair
Tenofovir
Pharmacokinetics
Concentrations
Hair

Additional relevant MeSH terms:
Tenofovir
Tenofovir disoproxil
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Therapeutic Uses
Anti-HIV Agents

ClinicalTrials.gov processed this record on July 23, 2014