Inclusion Criteria:

• Female patients must be post-menopausal
• Patient has a BMI of at least 29 kg/m^2
• Patient's weight has been stable over the past 3 months
• Patient has never been treated for hypertension or is diagnosed with hypertension taking up to 2 anti-hypertensive medications
• Patient is willing to stop hypertension treatment for 14 days prior to randomization and throughout the study
• Patient does not have a history of diabetes
• Patient is in good health with the exception of hypertension
• Patient has no history of abnormal heart rhythms
• Part I only: Patient is willing to comply with high potassium/low sodium diet for the duration of the study
• Patient is willing to avoid strenuous physical activity during the study
• Patient is a nonsmoker and/or has not used nicotine for at least 3 months and agrees to refrain from use of tobacco-containing products throughout the study
• Patient agrees to refrain from consuming alcohol and caffeine during in-patient periods and to limit consumption at all other times during the study
• Patient agrees not to consume grapefruit, grapefruit products, and citrus, apple, and pineapple juices 2 weeks prior to administration of the first dose of study drug

Exclusion Criteria:

• Patient has a history of any illness that may make their participation in the study unsafe or confuse the study results
• Patient is taking spironolactone or eplerenone
• Patient cannot refrain from using any prescription or non-prescription drugs during the study
• Patient is on a weight loss program and is not in the maintenance phase
• Patient started a weight loss drug within 8 weeks of the first study visit
• Patient consumes excessive amounts of alcohol or caffeine
• Patient has had major surgery, donated or lost 1 unit of blood within 4 weeks of the first study visit
• Patient has a history of multiple and/or severe allergies to drugs or food
• Patient is dehydrated