A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs
The goal of this study is to determine the association between genotypes and diet. The weight and weight loss data are already available from the previously completed study called: A to Z Study - Benefits and Risks of Alternative Weight Loss Strategies - A Clinical Trial, which was performed from 2003-2005 at Stanford University. In the present study, Interleukin Genetics will obtain DNA samples from the previously enrolled study subjects to investigate genetic influence of the response to macronutrient compositions of low caloric diets to weight loss.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs|
- The PRIMARY objective of this study is to identify genotype-diet interaction on weight, body fat, and BMI. [ Time Frame: 1 year ] [ Designated as safety issue: No ]
- The SECONDARY objective is to explore the association of single nucleotide polymorphisms (SNPs) with other metabolic parameters, such as blood lipid profile, insulin level, and other cardiovascular risk factors. [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Buccal swabs are collected by Stanford and sent to Interleukin Genetics for genotyping.
|Study Start Date:||August 2008|
|Estimated Study Completion Date:||September 2009|
|Estimated Primary Completion Date:||June 2009 (Final data collection date for primary outcome measure)|
Previously enrolled subjects in the "Benefits and Risks of Alternative Weight Loss Strategies - a Clinical Trial", which was run at Stanford 2003-2005. (A to Z Study)
Interleukin Genetics has derived, through an extensive search of the scientific literature, a genetic test panel in the area of Weight Management (WM), which includes the genes that have been shown to affect body weight. These genes have been associated with elevated risk for obesity.
|United States, California|
|Stanford, California, United States, 94305-5401|
|Principal Investigator:||Christopher Gardner, PhD||Stanford University|