Inclusion Criteria:

• Patient has not taken common statins or ezetimibe within 6 weeks of study screening or patient is currently taking a daily dose of the following statins for 6 weeks prior to study screening: simvastatin, atorvastatin, pravastatin, fluvastatin, ezetimibe, lovastatin, or ezetimibe + fluvastatin
• Patient is willing to go on a cholesterol and glucose lowering diet for the duration of the study
• Patient is willing to remain abstinent or use birth control for the duration of the study
• Patient has Diabetes Mellitus with cardiovascular disease

Exclusion Criteria:

• Patient has sensitivity to certain common statin drugs
• Patient is Asian and would not be able to start taking the higher doses of rosuvastatin necessary for the study design
• Patient consumes more than 2 alcoholic drinks per day
• Patient is pregnant or breast-feeding
• Patient has been treated with other investigational drugs within 30 days of first visit
• Patient is currently on prohibited doses of the following statin drugs: rosuvastatin, simvastatin, atorvastatin, and pravastatin
• Patient has congestive heart failure
• Patient has uncontrolled high blood pressure
• Patient has kidney disease
• Patient has uncontrolled endocrine or metabolic disease which are known to possibly increase blood lipoproteins
• Patient has diabetes mellitus that is not well controlled
• Patient is HIV positive
• Patient is currently taking medications that inhibit CYP3A4
• Patient is currently taking therapies that would increase the risk of muscle weakness
• Patient has been taking certain over- the-counter lipid-lowering agents within 6 weeks prior to visit 1
• Patient is currently taking psyllium or other fiber-based laxatives.