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| Sponsor: | Holstebro Hospital |
|---|---|
| Information provided by: | Holstebro Hospital |
| ClinicalTrials.gov Identifier: | NCT00857909 |
Purpose
This study will investigate whether retaining potassiom in the body will lead to changes in blood pressure and changes in blood and urine samples.
| Condition | Intervention | Phase |
|---|---|---|
|
High Blood Pressure |
Drug: Amiloride Drug: Spironolactone Drug: Placebo |
Phase I |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment |
| Official Title: | The Effect of Amiloride and Spironolactone Measured on Cardiovascular and Kidney Related Variables in Healthy Subjects in a Double-Blinded, Randomised, Placebo-Controlled, Cross-Over Study |
| Estimated Enrollment: | 25 |
| Study Start Date: | January 2009 |
| Estimated Study Completion Date: | November 2010 |
| Estimated Primary Completion Date: | November 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
1: Active Comparator
Amiloride
|
Drug: Amiloride
1 tablet twica a day
|
|
2: Active Comparator
Spironolactone
|
Drug: Spironolactone
1 tablet twice a day
|
|
Placebo: Placebo Comparator
calcium tablet
|
Drug: Placebo
Placebo
|
Eligibility| Ages Eligible for Study: | 18 Years to 40 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Denmark | |
| Medical Research | Recruiting |
| Holstebro, Denmark, 7500 | |
| Contact: Solveig Klok Matthesen, Cand. med +4599125000 ext 5427 cirkussolveig@hotmail.com | |
More Information
| Responsible Party: | Medical Research Department ( Erling Bjerregaard Pedersen/ Dr. Med ) |
| Study ID Numbers: | MED.RES:HOS:SKM.02.2009 |
| Study First Received: | March 6, 2009 |
| Last Updated: | March 6, 2009 |
| ClinicalTrials.gov Identifier: | NCT00857909 History of Changes |
| Health Authority: | Denmark: Danish Dataprotection Agency |
|
Molecular Mechanisms of Pharmacological Action Hormone Antagonists Physiological Effects of Drugs Diuretics Hormones, Hormone Substitutes, and Hormone Antagonists Vascular Diseases Amiloride Cardiovascular Agents Pharmacologic Actions |
Spironolactone Membrane Transport Modulators Aldosterone Antagonists Natriuretic Agents Therapeutic Uses Cardiovascular Diseases Sodium Channel Blockers Hypertension |
