Cerebral Toxoplasmosis and AIDS (TOXODFA)
With a HIV incidence much higher in the DFA than in European French territory, this disease is a major public health problem in these areas, especially in French Guiana.
Cerebral toxoplasmosis is a priority among the opportunistic infections in AIDS patients from the DFA because of its frequency (French West Indies) and of its lethality (French Guiana).
The diagnosis of cerebral toxoplasmosis may be difficult because based only on presumptive clinical and radiological features. The response to specific antitoxoplasmic therapy confirms a posteriori the diagnosis.
In reference to the data collected by the Biological Resource Centre Toxoplasma, in particular in French Guiana, we think that T. gondii strains reactivating in AIDS patients from DFA are genetically different from those reactivating in AIDS patients from Europe, with an increased capacity for dissemination via peripheral blood in the first ones. This more frequent or more prolonged parasitemia could facilitate the diagnosis of cerebral toxoplasmosis by PCR test from peripheral blood samples in AIDS patients from the French departments of America.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Cerebral Toxoplasmosis and AIDS in the French Departments of America (DFA). Diagnostic Contribution of a PCR Assay and Genetic Diversity of Toxoplasma Gondii.|
- Isolation, genetic typing and storage of T. gondii strains collected among AIDS patients with cerebral toxoplasmosis from the DFA. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
|Study Start Date:||June 2009|
|Study Completion Date:||December 2013|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Other: Toxoplasma PCR assay
|Service des Maladies Infectieuses - CHU de Pointe à Pitre|
|Pointe à Pitre, Guadeloupe, France|
|Services Maladies Infectieuses et Tropicales- CHU Fort-de-France|
|Médecine- CH Ouest Guyanais|
|Maladies Infectieuses et Tropicales - CH Andrée Rosemon|
|Dermatologie et CISIH- CH Andrée Rosemon|
|Study Director:||Daniel AJZENBERG, PharmD, PhD||CHU Limoges|