Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00745888
First received: September 2, 2008
Last updated: September 4, 2009
Last verified: August 2009
  Purpose

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.


Condition Intervention Phase
Sepsis
Shock
Other: Chemiluminescence Analyzer
Phase 3

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • 28-day Survival [ Time Frame: 28 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Days stay in ICU Days on ventilator SOFA score Complications [ Time Frame: 28 days ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

blood sample


Estimated Enrollment: 200
Study Start Date: May 2007
Groups/Cohorts Assigned Interventions
1
age > 18 y/o Patients admitted to surgical ICU
Other: Chemiluminescence Analyzer
measure reactive oxygen species

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients admitted to surgical ICU

Criteria

Inclusion Criteria:

  • Age > 18 y/o
  • Admitted to surgical ICU

Exclusion Criteria:

  • Patients with brain death
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00745888

Contacts
Contact: Yu-Chang Yeh, MD 886-9-68661829 tonyyeh@ntuh.gov.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yu-Chang Yeh, MD    886-9-68661829    tonyyeh@ntuh.gov.tw   
Principal Investigator: Yu-Chang Yeh, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Yu-Chang Yeh National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: Yu-Chang Yeh, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00745888     History of Changes
Other Study ID Numbers: 9561709132
Study First Received: September 2, 2008
Last Updated: September 4, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
oxidative stress
intensive care
Postoperative intensive care

ClinicalTrials.gov processed this record on October 21, 2014