Physical Activity in Youth: Implications for Reversing Risk Factors for Type 2 Diabetes

This study has been completed.
American Diabetes Association
Information provided by (Responsible Party):
SoJung Lee, University of Pittsburgh Identifier:
First received: August 20, 2008
Last updated: November 2, 2012
Last verified: October 2012

In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, and risk of type 2 diabetes in overweight children and adolescents.

Condition Intervention
Abdominal Obesity
Other: Control
Other: Resistance Exercise
Other: Aerobic exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Physical Activity in Youth: Implications for Reversing Risk Factors for Type 2 Diabetes

Resource links provided by NLM:

Further study details as provided by University of Pittsburgh:

Primary Outcome Measures:
  • Abdominal obesity, visceral fat [ Time Frame: 3 month ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Insulin sensitivity and secretion, glucose tolerance [ Time Frame: 3 month ] [ Designated as safety issue: No ]

Enrollment: 45
Study Start Date: November 2007
Study Completion Date: October 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Standard care control
Other: Control
Standard care control (no exercise)
Active Comparator: Aerobic Exercise Other: Aerobic exercise
Supervised aerobic exercise using treadmills, bikes, and ellipticals
Active Comparator: Resistance Exercise Other: Resistance Exercise
Supervised resistance exercise using stack weight equipments.


Ages Eligible for Study:   12 Years to 18 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy overweight (BMI >-95th) youth between 12 and 18 years of age
  • Waist circumference >-75th percentile
  • Sedentary (no structured exercise >2 times/week for past 6 months)
  • Non-smokers, non-diabetic, no medical conditions
  • Weight stable for past 3 months

Exclusion Criteria:

  • Smokers,
  • diabetic,
  • psychiatric disorders,
  • syndromatic obesity
  Contacts and Locations
Please refer to this study by its identifier: NCT00739180

United States, Pennsylvania
Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
American Diabetes Association
Principal Investigator: SoJung Lee, PhD University of Pittsburgh
  More Information

No publications provided

Responsible Party: SoJung Lee, Assistant Professor of Pediatrics, University of Pittsburgh Identifier: NCT00739180     History of Changes
Other Study ID Numbers: 7-08-JF-27
Study First Received: August 20, 2008
Last Updated: November 2, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of Pittsburgh:
Childhood obesity
Abdominal obesity
Visceral fat
Insulin resistance
Liver fat
Skeletal muscle lipid

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Obesity, Abdominal
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Nutrition Disorders
Body Weight
Signs and Symptoms processed this record on April 17, 2014