Absorption Kinetics of Polyphenols in Angel's Plant (Angelica Keiskei)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by Tufts University.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Tufts University
ClinicalTrials.gov Identifier:
NCT00721643
First received: July 22, 2008
Last updated: August 24, 2009
Last verified: August 2009
  Purpose

The absorption kinetics of polyphenols in angel's plant (Angelica keiskei), which is a dark green leafy vegetable rich in antioxidant nutrients, will be determined in older adults in this pilot study.


Condition Intervention Phase
Oxidative Stress
Dietary Supplement: angel's plant (Angelica keiskei)
Dietary Supplement: Angel's plant (Angelica keiskei)
Phase 0

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Absorption Kinetics of Polyphenols in Angel's Plant (Angelica Keiskei)

Further study details as provided by Tufts University:

Primary Outcome Measures:
  • Plasma quercetin [ Time Frame: 0, 30, 60, 100, 180, 240, 300, 360, 420 & 480 min ] [ Designated as safety issue: No ]

Enrollment: 10
Study Start Date: July 2008
Estimated Study Completion Date: December 2010
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Healthy control, 5g dry power of angel's plant (Angelica keiskei)
Dietary Supplement: angel's plant (Angelica keiskei)
Healthy control, one time dose of 5g dry power of Angelica keiskei
Experimental: 2
Metabolic syndrome, 5g dry powder of angel's plant (Angelica keiskei)
Dietary Supplement: Angel's plant (Angelica keiskei)
Metaboic syndrome subjects, one time dose of 5g dry powder of angel's plant (Angelica keiskei)

  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects (>60 yr, n=5)
  • subjects with metabolic syndrome (>60 yr, n=5)
  • Subjects who has

    • high fasting plasma glucose (>5.6 mmol/L),
    • central obesity (waist-hip ratio, >0.9 for men, >0.85 for women)
    • either high blood pressure (>130/85 mmHg) or high triacylglycerol (>1.7 mmol/L) will be selected to have metabolic syndrome.
  • normal hematological parameters, normal serum albumin, normal liver function, and normal kidney function
  • no history of smoking or alcoholism.

Exclusion Criteria:

  • consume >7 alcoholic drinks/wk
  • taking cholesterol medication or hormone replacement
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00721643

Locations
United States, Massachusetts
Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111
Sponsors and Collaborators
Tufts University
Investigators
Principal Investigator: Kyung-Jin Yeum, Ph.D. Tufts Medical Center
  More Information

No publications provided

Responsible Party: Kyung-Jin Yeum, Scientist, Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University
ClinicalTrials.gov Identifier: NCT00721643     History of Changes
Other Study ID Numbers: HNRCA2580, BioGreen 20070301034009
Study First Received: July 22, 2008
Last Updated: August 24, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by Tufts University:
Angelica keiskei
absorption kinetics
quercetin

ClinicalTrials.gov processed this record on September 18, 2014