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Efficacy of Transference-Focused Psychotherapy for Borderline Personality Disorder

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2008 by University Hospital Muenster.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
University Hospital Muenster
ClinicalTrials.gov Identifier:
NCT00714311
First received: July 9, 2008
Last updated: February 13, 2009
Last verified: July 2008
History of Changes
  Purpose

The purpose of this study is to find out whether Transference-Focused Psychotherapy (TFP) is effective in the treatment of Borderline Personality Disorder.


Condition Intervention
Borderline Personality Disorder
 Behavioral: Transference-Focused Psychotherapy
Behavioral: treatment by experienced community psychotherapists

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized-Controlled Trial of Transference-Focused Psychotherapy vs. Treatment by Experienced Community Psychotherapists for Borderline Personality Disorder

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital Muenster:

Primary Outcome Measures:
  • Drop-out [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Suicidality (suicide attempts) [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Psychosocial Functioning (Global Assessment of Functioning, GAF-Score) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Level of personality organization (Structured Interview for Personality Organization, STIPO) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Number of self-harming acts [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Self-assessment of psychopathology (BDI, STAI, BSI) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Attachment style and Reflective Function (Adult Attachment Interview, AAI) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
  • Borderline symptomatology (DSM-IV criteria) [ Time Frame: 1 month ] [ Designated as safety issue: No ]

Enrollment: 104
Study Start Date: October 2004
Estimated Study Completion Date: February 2012
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: TFP
Transference-Focused Psychotherapy
 Behavioral: Transference-Focused Psychotherapy
Outpatient psychotherapy according to the treatment manual, sessions of 50 minutes twice per week
Active Comparator: ECP
treatment by experienced community psychotherapists
 Behavioral: treatment by experienced community psychotherapists
Outpatient psychotherapy in private practices or outpatient units of psychiatric hospitals. Licensed psychotherapists with experience and special interest in the treatment of borderline patients are treating according to the method they have learned.

Detailed Description:

Borderline personality disorder represents a sever clinical condition that affects 1-2% of the community and is characterized by a pervasive instability of interpersonal relationships, self-image, and affects, as well as a marked impulsivity; up to 10% of the patients commit suicide.

Transference-Focused Psychotherapy (TFP) is one psychotherapeutic approach among five that have been manualized and evaluated in RCTs. So far, TFP has not been compared to a control condition which is a crucial step in the evaluation of the efficacy of a psychosocial intervention.

This study is an RCT that compares one year of outpatient TFP to treatment by experienced community psychotherapists for borderline personality disorder.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Written informed consent to the participation in the study
  • Diagnosis of BPD according to DSM-IV as assessed using the SCID-II
  • Age between 18 and 45 years
  • Sufficient knowledge of the German language

Exclusion Criteria:

  • Diagnosis of schizophrenia, bipolar disorder, severe substance abuse, organic pathology, or mental retardation according to DSM-IV as assessed using the SCID-I
  • Diagnosis of antisocial personality disorder according to DSM-IV as assessed using the SCID-II
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00714311

Locations
Austria
Dept. of Psychoanalysis and Psychotherapy, Medical University Vienna
Vienna, Austria, 1090
Germany
Dept. of Psychiatry, Technical University of Munich
Munich, Bavaria, Germany, 81675
Sponsors and Collaborators
University Hospital Muenster
Investigators
Principal Investigator: Stephan Doering, MD University of Muenster, Germany
  More Information

Publications:

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Stephan Doering, MD, University of Muenster, Germany
ClinicalTrials.gov Identifier: NCT00714311     History of Changes
Other Study ID Numbers: 1106/04, 10636, DPG0802
Study First Received: July 9, 2008
Last Updated: February 13, 2009
Health Authority: Germany: Ethics Commission

Keywords provided by University Hospital Muenster:
borderline personality disorder
randomized controlled trial
Transference-Focused Psychotherapy
treatment by experienced community psychotherapists

Additional relevant MeSH terms:
Personality Disorders
Borderline Personality Disorder
Mental Disorders

ClinicalTrials.gov processed this record on May 23, 2013