Sleepiness and Brain Function: The Effect of Armodafinil in Shift Work Sleep Disorder
The investigators hypothesize that in patients with shift work sleep disorder, armodafinil will specifically increase brain activity in the frontal cortex parallel with improvements in deficits of fundamental mechanisms of attention.
Shift Work Sleep Disorder
|Study Design:||Time Perspective: Prospective|
|Official Title:||Magnetoencephalographic Imaging of Sleepiness: The Effect of Armodafinil in Shift Work Sleep Disorder|
|Study Start Date:||February 2008|
|Study Completion Date:||March 2010|
|Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
Individuals with shift work sleep disorder
Healthy night shift workers without shift work sleep disorder
The current protocol will utilize a paradigm which is well suited to examine frontal attentional neuronal mechanisms by eliciting event related potential components known to reflect automatic stimulus detection as well as involuntary and voluntary attentional processes. The that end the proposed research has two specific aims. 1) Identify what areas of the frontal lobe and corresponding cognitive functions are impacted by excessive sleepiness in shift work sleep disorder and 2) identify specific brain areas affected by armodafinil and their role in improvement of fundamental attentional processes using a complex cognitive task targeting attentional control.
|United States, Michigan|
|Henry Ford Hospital Sleep Disorders & Research Center|
|Detroit, Michigan, United States, 48202|
|Principal Investigator:||Christopher Drake, Ph.D.||Henry Ford Hospital Sleep Disorders & Research Center|