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Psychotherapy for Intermittent Explosive Disorder

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Chicago
ClinicalTrials.gov Identifier:
NCT00667212
First received: April 24, 2008
Last updated: June 11, 2013
Last verified: December 2010
  Purpose

The goal of this study is to examine the effectiveness two forms of psychotherapy (also known as "talk therapy" ) for individuals with anger and aggression problems. Anger and aggression are everywhere - on the road, in the schools, at little league games, at home, and at work. In this study we are testing usefulness of anger management techniques in reducing symptoms of Intermittent Explosive Disorder (IED) and impulsive, aggressive behavior.


Condition Intervention Phase
Anger
Intermittent Explosive Disorder
Behavioral: Cognitive Behavioral Therapy
Behavioral: Supportive Psychotherapy
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Individual Cognitive Behavioral Psychotherapy for Intermittent Explosive Disorder

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Overt Aggression Scale - Modified (OASM) [ Time Frame: Screen Visit, Pre-Therapy visit, Therapy sessions 2, 4, 6, 8, 12, Post-Therapy Visit, 3, 6, and 12-month Follow-Up Vists ] [ Designated as safety issue: No ]
  • State-Trait Anger Expression Inventory - Trait Anger Scale [STAXI-T] [ Time Frame: Pre-Therapy visit, Therapy session 7, Post-Therapy visit ] [ Designated as safety issue: No ]
  • Intermittent Explosive Disorder Interview [ Time Frame: Diagnostic Interview, Post-Therapy Visit (Modified), 3, 6, and 12-month Follow-Up vists (modified) ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Behavioral aggression measures (Taylor Aggression Paradigm [TAP], Point Subtraction Aggression Paradigm [PSAP]) [ Time Frame: Pre-Therapy Visit, Post-Therapy Visit, 3, 6, and 12-month Follow-Up visits ] [ Designated as safety issue: No ]

Enrollment: 60
Study Start Date: August 2006
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 2
Supportive Psychotherapy
Behavioral: Supportive Psychotherapy
Twelve weekly therapy sessions, approximately one hour each in duration
Active Comparator: 1
Cognitive Behavioral Therapy (Cognitive Restructuring, Relaxation, and Coping Skills Training: CRCST)
Behavioral: Cognitive Behavioral Therapy
Twelve weekly therapy sessions, approximately one hour each in duration
Other Name: Cognitive Restructuring, Relaxation, and Coping Skills Training

Detailed Description:

Qualified participants will be randomly assigned to 12 1-hour sessions of either cognitive-behavioral therapy or supportive psychotherapy.

Participation in this study will require 16 visits over approximately 4 months with 3 follow-up sessions over a 12 month period. Therapy is provided at no cost and each study participant will receive a comprehensive psychological assessment. Two types of talk therapy are being offered in this study. One form of therapy focuses on thought and behaviors associated with anger and aggression. This type of therapy is known as cognitive behavioral therapy. The other type of therapy focuses on the individuals' feeling about their anger /aggression and the situations that lead to this anger. This is known as supportive therapy. The form of therapy you are given will be randomly determined (like by flipping of a coin).

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Have problems with anger, temper outbursts, being irritable, getting in trouble at work or at home because of impulsive/aggressive behavior.
  • Between the ages of 18 and 55.
  • Meet other eligibility requirements as outlined by the research protocol.

Exclusion Criteria:

  • CHECK ON THIS
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00667212

Locations
United States, Illinois
University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: Michael McCloskey, PhD University of Chicago
  More Information

No publications provided

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00667212     History of Changes
Other Study ID Numbers: 15143A
Study First Received: April 24, 2008
Last Updated: June 11, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Chicago:
anger
intermittent
explosive

Additional relevant MeSH terms:
Disease
Impulse Control Disorders
Mental Disorders
Pathologic Processes

ClinicalTrials.gov processed this record on November 24, 2014