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Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

This study has been completed.

Sponsored by: Tottori University Hospital
Information provided by: Tottori University Hospital
ClinicalTrials.gov Identifier: NCT00664222
  Purpose

The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.


Condition Intervention Phase
Chronic Stable Heart Failure
Drug: spironolactone + furosemide
Phase IV

MedlinePlus related topics:   Heart Failure   

Drug Information available for:   Insulin    Spironolactone    Furosemide   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Randomized, Double Blind (Subject, Investigator), Active Control, Crossover Assignment, Efficacy Study
Official Title:   Effects of Spironolactone on Insulin Resistance in Patients With Chronic Heart Failure

Further study details as provided by Tottori University Hospital:

Primary Outcome Measures:
  • insulin resistance [ Time Frame: 16 weeks ]

Enrollment:   16
Study Start Date:   January 2004
Estimated Study Completion Date:   December 2005

Intervention Details:
    Drug: spironolactone + furosemide
    spironolactone 25mg/day, 16 weeks and furosemide 20mg/day, 16weeks
Detailed Description:

Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

  Eligibility
Genders Eligible for Study:   Both

Criteria

Inclusion Criteria:

  • chronic stable heart failure

Exclusion Criteria:

  • renal dysfunction or under treatment with antidiabetic agents
  Contacts and Locations

No Contacts or Locations Provided
  More Information


Responsible Party:   Center for Clinical Residency Program, Tottori University Hospital ( Kazuhide Ogino, MD )
Study ID Numbers:   #344.1
First Received:   April 18, 2008
Last Updated:   April 21, 2008
ClinicalTrials.gov Identifier:   NCT00664222
Health Authority:   Japan: Ministry of Health, Labor and Welfare

Keywords provided by Tottori University Hospital:
heart failure  
insulin resistance  
inflammatory cytokine  
spironolactone  
furosemide  

Study placed in the following topic categories:
Hyperinsulinism
Heart Failure
Metabolic Diseases
Heart Diseases
Insulin Resistance
Metabolic disorder
Glucose Metabolism Disorders
Furosemide
Insulin
Spironolactone

Additional relevant MeSH terms:
Molecular Mechanisms of Pharmacological Action
Hormone Antagonists
Diuretics
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Cardiovascular Agents
Pharmacologic Actions
Membrane Transport Modulators
Aldosterone Antagonists
Natriuretic Agents
Therapeutic Uses
Cardiovascular Diseases
Sodium Potassium Chloride Symporter Inhibitors

ClinicalTrials.gov processed this record on November 20, 2008




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