Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2008 by Soroka University Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Soroka University Medical Center
ClinicalTrials.gov Identifier:
NCT00660465
First received: April 15, 2008
Last updated: April 16, 2008
Last verified: February 2008
  Purpose

The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .


Condition
Healthy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .

Resource links provided by NLM:


Further study details as provided by Soroka University Medical Center:

Estimated Enrollment: 6
Study Start Date: May 2008

Detailed Description:

Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

residents

Criteria

Inclusion Criteria:

  • adults over 18 years old .

Exclusion Criteria:

  • under 18 years old.
  • Artificial pacemaker
  • implantable cardioverter-defibrillator (ICD)
  • Hearing aid, implantable or portable.
  • artificial heart valve
  • Surgical clips
  • Metal fragments in eyes
  • Electronic stimulators
  • Implanted pumps
  • Implantable Neurostimulation Device
  • metal fragments of any sort
  • Permanent makeup or tattoo
  • transfusion pump
  • pregnant or breast feeding women
  • False teeth , retainer or dental crown
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00660465

Contacts
Contact: Alexander Gersten, Ph.D +972-52-3906012 alex.gersten@gmail.com

Locations
Israel
Department of Diagnostic Imaging ;Soroka Univrsity Medical Center Recruiting
Beer Sheva, Israel, 84101
Contact: Ilan Shelef, M.D    +972-8-6403950    shelef@bgu.ac.il   
Sub-Investigator: Alexander Gersten, Ph.D         
Sub-Investigator: Batel Lasry         
Sponsors and Collaborators
Soroka University Medical Center
Investigators
Study Director: Ilan Shelef, M.D Head, Neuroradiolgy Unit ;Department of Diagnostic Imaging ;Soroka Univrsity Medical Center
  More Information

No publications provided

Responsible Party: Alexander Gersten, Ben-Gurion University of the Negev
ClinicalTrials.gov Identifier: NCT00660465     History of Changes
Other Study ID Numbers: SOR467608CTIL
Study First Received: April 15, 2008
Last Updated: April 16, 2008
Health Authority: Israel: Ministry of Health

Keywords provided by Soroka University Medical Center:
Regional BOLD signal dependency on arterial PaCO2.
Effect of breathing exercises on brain regional O2 level.
Healthy subjects

ClinicalTrials.gov processed this record on September 18, 2014