Inclusion Criteria:

• Be aged 30 to 85 years.
• Be male or female - female patients must be either not of childbearing potential (defined as post menopausal for at least one year or surgically incapable of bearing children), or must be practicing contraceptive methods as outlined in the protocol.
• Have a clinical diagnosis of idiopathic Parkinson's Disease, exhibiting at least 2 of 3 symptoms (rigidity, resting tremor, bradykinesia)
• Have non-motor symptoms of end of dose wearing off i.e., the presence of at least one non-motor symptom of Parkinson's Disease which improves with the next immediate release (IR) carbidopa/levodopa dose as determined by the Quantitative Wearing-Off Questionnaire 9 and investigator's assessment. At least one non-motor item has to show a severity of at least 2 points (of a maximum of 4) and show an improvement of at least 1 one hour after immediate release (IR) carbidopa/levodopa administration. (all criteria must be fulfilled)
• Be taking a stable dose of immediate release (IR) carbidopa/levodopa for at least 28 days prior to randomization at an equivalent total daily dose of immediate release (IR) carbidopa/levodopa between 300 to 600 mg. Dosing should be either 3 or 4 times per day.
• Be capable of satisfying the requirements of the protocol and must be willing and able to give informed consent according to legal requirements.

Exclusion Criteria:

• Have a previous history of being non-responsive to entacapone or tolcapone treatment or having experienced a serious or severe adverse event(s) which resulted in the discontinuation of treatment from the previous use of entacapone or tolcapone; current treatment with entacapone or tolcapone or discontinued treatment with either therapy or discontinued less than 60 days before randomization;
• Have a history, signs, or symptoms suggesting a diagnosis of secondary or atypical parkinsonism;
• Have unstable Parkinson's Disease requiring frequent booster doses;
• Disabling dyskinesias, indicated by a score of greater than 1 on Unified Parkinson Disease Rating Scale question #32, or a score of greater than 1 on Unified Parkinson Disease Rating Scale question #33;
• Have a history or current diagnosis of psychotic features according to the investigator;
• Have a history or current diagnosis of symptoms of an impulse control disorder according to a screening assessment with the modified Minnesota Impulsive Disorders Interview and the investigator's judgment;
• Have a diagnosis of Bipolar Disorder I or II according to the Diagnostic Statistical Manual, Fourth Edition;
• Demonstrate indications of marked suicidal tendencies as assessed by the investigator;
• Have undergone psychotherapy or psychiatric pharmacotherapy, currently or within 28 days prior to randomization;
• If female, be pregnant, trying to become pregnant or nursing an infant;
• Diagnostic and Statistical Manual, Fourth Edition, Text Revision; [American Psychiatric Association, 2000] diagnosis of 1. dementia (of any cause); 2. moderate or severe major depression, present independent from the time of first diagnosis of Parkinson's Disease, as defined by a Quick Inventory of Depressive Symptomatology -Self Rating 16 score of > 15; or 3. generalized anxiety disorder or panic disorder if made prior to the diagnosis of Parkinson's Disease;
• Have received treatment with MAO-inhibitors;
• Diagnostic and Statistical Manual, Fourth Edition, Text Revision diagnosis of alcohol or substance abuse (excluding nicotine or caffeine) during the 3 months prior to randomization) or alcohol or substance dependence (excluding nicotine or caffeine) during the 6 months prior to randomization. Alcohol should be avoided within the 12 hours preceding the Screening, Baseline, Week 2 and Week 8 visits;
• Diagnostic and Statistical Manual, Fourth Edition, Text Revision diagnosis of dysthymia within the last 12 months;
• Have a history or current diagnosis of malignancy of any organ system, treated or untreated, within the past 5 years whether or not there is evidence of local recurrence or metastases, with the exception of localized basal cell carcinoma of the skin.

Other protocol-defined inclusion/exclusion criteria may apply