A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites (GCNKSS)
Our primary goal is to study temporal trends in the incidence rate, causes, treatment, and outcome of stroke among a large biracial metropolitan population of 1,349,351, of whom 215,611 (15%) are black (2000 Census). Such data are critical for the planning, intervention, and evaluation of public health efforts to decrease the mortality and morbidity due to stroke in the United States.
For calendar years 1993-94, 1999, 2005, and 2010 we will identify every hospitalized or autopsied stroke and transient ischemic attack (TIA) at all regional hospitals in our region. We will also estimate the number of non-hospitalized strokes and TIAs by screening for potential cases at more than 100 outpatient sites throughout five counties in Greater Cincinnati/Northern Kentucky. We plan to identify and abstract detailed information from the medical record for every potential case. These results will be compared with data from all stroke patients identified by similar methodology in all study periods. In addition, we have interview 500 ischemic stroke patients and/or their families(each study year period starting in 1999), to obtain detailed information including demographic information, functional outcome and quality of life, access to and type of rehabilitation therapy, social support, caregiver availability and health status, access to post-hospital care, health insurance status, current health status, medications, prior risk factors, and knowledge about stroke signs and symptoms. We will also obtain genetic material via a blood sample.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites: A Population-Based Study in Cincinnati, Ohio|
- mRS [ Time Frame: 30 days ] [ Designated as safety issue: No ]modified Rankin Scale
- mortality [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
In 2010 we have a prospectively collected a cohort of 516 of which 396 provided a blood sample for DNA to be stored at the University of Cincinnati. We have 450 samples stored from the 2005 cohort.
|Study Start Date:||July 1993|
|Estimated Study Completion Date:||June 2014|
|Estimated Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
We prospectively collected 450(1999), 502(2005), and 512(2010) ischemic stroke patients who agreed to participate and also most provided a sample for DNA. The cohort data consists of a baseline interview, medical record abstraction and various timeframes of followup interviews from 3m to 3yrs.
The second part of the study is a retrospective medical record review of all potential ischemic strokes, TIAs, and Hemorrhagic strokes in our 5 county region that occurred all study years.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00642213
|United States, Ohio|
|University of Cincinnati|
|Cincinnati, Ohio, United States, 45267-0525|
|Principal Investigator:||Brett M Kissela, MD||University of Cincinnati|