Inclusion Criteria:

Subjects must meet the following inclusion criteria:

1. 18 years of age or older;
2. have mild to moderate hand dermatitis, according to Investigator Global Assessment (see below);
3. be generally healthy, as determined by brief medical history;
4. have a negative urine test for pregnancy if female, and use of highly effective method of birth control, such as condoms & spermacide, implants, injectables, combined oral contraceptives, intrauterine device (IUD's), sexual abstinence, or a vasectomized partner. For subjects using a hormonal contraceptive method, [i.e., birth control pill (BCP)], the dose and type of BCP should stay constant 1 month prior to enrollment and throughout the study, and
5. be capable of understanding and signing the consent form.

Exclusion Criteria:

Subjects will be excluded from the study if they:

1. have clinically relevant allergic or irritant contact dermatitis and the inability to avoid exposure;
2. have severe and very severe hand dermatitis according to the Investigator Global Assessment;
3. have severe vesiculation or bullae;
4. have a history of psoriasis, contact urticaria, and/or pustular diseases of the hands;
5. have had therapy of the hands with potent topical corticosteroids within one month of enrollment;
6. have used systemic treatment with oral retinoids, corticosteroids, or with PUVA within the 8 week period prior to the beginning of the study
7. have a history of alcoholism or drug abuse;
8. have a history or current evidence of a chronic or infectious skin disease; and
9. are pregnant or lactating females, or using method of birth control that does not comply with highly effective methods of birth control listed under inclusion criteria; Pregnant or lactating females, or using method of birth control that does not comply with highly effective methods of birth control listed under inclusion criteria.