Effects of Acetaminophen on Hurt Feelings

This study has been completed.
Information provided by:
University of Toronto
ClinicalTrials.gov Identifier:
First received: November 16, 2007
Last updated: June 23, 2008
Last verified: June 2008

The purpose of the study is to investigate whether ingestion of acetaminophen reduces the experience of hurt feelings.

Condition Intervention
Emotional Pain
Drug: acetaminophen
Other: cornstarch

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Acetaminophen on Hurt Feelings

Resource links provided by NLM:

Further study details as provided by University of Toronto:

Primary Outcome Measures:
  • Self-reported daily hurt feelings [ Time Frame: 21 days ]

Secondary Outcome Measures:
  • Reports of emotional states other than hurt feelings [ Time Frame: 21 days ]
  • Evaluations of self-worth [ Time Frame: 21 days ]

Enrollment: 60
Study Start Date: November 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
2000 mg acetaminophen per day
Drug: acetaminophen
2 x 1000 mg doses per day
Placebo Comparator: 2
2000 mg cornstarch per day
Other: cornstarch
2 x 1000 mg cornstarch per day


Ages Eligible for Study:   17 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • University of Toronto undergraduate psychology student

Exclusion Criteria:

  • Alcohol consumption (more than 2 drinks per day)
  • Intake of enzyme-inducing drugs
  • Prolonged fasting/eating disorders/gastroenteritis
  • Intake of other over-the-counter or prescription analgesics
  • Liver Disorders
  • History of abuse treatment
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00561288

Canada, Ontario
University of Toronto
Toronto, Ontario, Canada, M5S 3G3
Sponsors and Collaborators
University of Toronto
Principal Investigator: Geoff MacDonald, Ph.D. University of Toronto
Principal Investigator: Nathan DeWall, Ph.D. University of Kentucky
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00561288     History of Changes
Other Study ID Numbers: 20619
Study First Received: November 16, 2007
Last Updated: June 23, 2008
Health Authority: Canada: Health Canada

Keywords provided by University of Toronto:
Social Psychology
Interpersonal Rejection

Additional relevant MeSH terms:
Physiological Effects of Drugs
Pharmacologic Actions
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 16, 2014