Motivation and Patch Treatment for HIV-Positive Smokers (Positive PATHS)
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Purpose
The purpose of this study is to develop and evaluate a brief, clinic-based smoking cessation treatment for an HIV+ population. We compared two treatments, a brief advice and follow-up plus nicotine patch treatment(Standard Care; SC) and brief advice and follow-up, nicotine patch, with the addition of a tailored motivational intervention and behavioral skills counseling for smoking cessation (Motivationally-Enhanced; ME), in a randomized controlled trial. We hypothesized that those HIV+ participants receiving the ME will demonstrate greater biochemically verified smoking abstinence rates at 6-month follow-up than those receiving the SC control treatment. All study participants were offered use of the nicotine patch.
| Condition | Intervention | Phase |
|---|---|---|
|
HIV Infections Smoking Cessation |
Behavioral: Standard Care Behavioral: Motivational Enhancement |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Motivation and Patch Treatment for HIV-Positive Smokers |
- smoking cessation [ Time Frame: 6-months ]
- smoking cessation [ Time Frame: 2- and 4-months ]
| Enrollment: | 444 |
| Study Start Date: | January 1999 |
| Study Completion Date: | December 2004 |
| Arms | Assigned Interventions |
|---|---|
| Experimental: Standard Care |
Behavioral: Standard Care
Brief advice and follow-up provided a smoking-cessation trained Health Educator PLUS nicotine patch
|
| Experimental: Motivational Enhancement |
Behavioral: Motivational Enhancement
Brief advice and follow-up, nicotine patch, and the addition of a tailored motivational intervention and behavioral skills counseling for smoking cessation.
|
Detailed Description:
Cigarette smoking is highly prevalent among HIV+ individuals, posing unique health risks, impacting HAART-therapy effectiveness, and possibly altering the course of the disease. To our knowledge, Motivation and Patch Treatment for HIV-Positive Individuals (Positive PATHS) was the first NIH-funded smoking cessation intervention designed to motivate HIV+ smokers to quit. Participants were referred by physicians at eight Immunology clinics in New England and randomized to receive either a brief, two-session intervention (Standard Care; SC) modeled on PHS guidelines, or a more intensive, four-session motivational counseling intervention (Motivational-Enhancement; ME). All physicians participating in the trial were trained in study eligibility criteria, as well as basic smoking cessation counseling strategies (based on the PHS guidelines). Interested individuals were then referred to the study, with a study researcher explaining the details of the study and obtaining informed consent. Participants were then assisted in completing baseline assessments via laptop computer, and then randomized to receive either a brief intervention (2-sessions) designed to reflect the standard of care in outpatient hospital settings and modeled on PHS guidelines (standard care; SC) or a more intensive (4-session) motivational counseling intervention (motivational enhancement; ME), with both interventions providing 8-weeks of nicotine replacement (patches; NRT) to those participants willing to set a quit date. Follow-up assessments, including biochemical verification of self-reported quitters (via carbon monoxide measurement) were conducted at 2, 4, and 6 months from baseline. This study is among the first to examine the health effects of a delivered smoking cessation intervention to an HIV+ population, with the results having implications for treatments in clinical care settings.
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Be receiving care for HIV at one of the participating immunology clinics
- Be 18 years old or older
- Be current (past 7 days) cigarette smoker
- Speak English or Spanish
Exclusion Criteria:
- Are pregnant or nursing
- Have uncontrolled hypertension
- Use other forms of tobacco like cigars or chewing tobacco or are using anything else to help with quitting smoking
- Are allergic to the nicotine patch or have a skin condition like eczema or psoriasis that makes them unable to use the patch
Contacts and Locations| United States, Massachusetts | |
| Stanley Street Treatment and Resources, Inc. | |
| Fall River, Massachusetts, United States, 02720 | |
| Greater New Bedford Community Center | |
| New Bedford, Massachusetts, United States, 02740 | |
| United States, Rhode Island | |
| Hope Center for HIV Care, Memorial Hospital | |
| Pawtucket, Rhode Island, United States, 02906 | |
| The Miriam Hospital Immunology Clinic | |
| Providence, Rhode Island, United States, 02906 | |
| Rhode Island Hospital HIV Clinic | |
| Providence, Rhode Island, United States, 02903 | |
| Principal Investigator: | Raymond Niaura, PhD | Brown University/Butler Hospital |
| Study Director: | Elizabeth Lloyd-Richardson, PhD | Brown University/The Miriam Hospital |
More Information
No publications provided by National Institute on Drug Abuse (NIDA)
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| ClinicalTrials.gov Identifier: | NCT00551720 History of Changes |
| Other Study ID Numbers: | R01 DA 12344 |
| Study First Received: | October 30, 2007 |
| Last Updated: | October 30, 2007 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institute on Drug Abuse (NIDA):
|
HIV HIV positive AIDS |
smoking cessation smoking smoking counseling |
Additional relevant MeSH terms:
|
HIV Infections Acquired Immunodeficiency Syndrome HIV Seropositivity Smoking Lentivirus Infections Retroviridae Infections RNA Virus Infections |
Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Habits |
ClinicalTrials.gov processed this record on May 16, 2013