The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD

This study is currently recruiting participants.

Verified by Samsung Medical Center, March 2006

First Received: October 3, 2007 Last Updated: October 4, 2007 History of Changes

Sponsor:	Samsung Medical Center
Information provided by:	Samsung Medical Center
ClinicalTrials.gov Identifier:	NCT00539786

Purpose

PPI test;empirical trial with high-dose proton-pump inhibitors (PPIs) has been shown to be a sensitive tool for diagnosing patients with GERD. However, this diagnostic strategy has not been well established in patients with extraesophageal manifestation of GERD. In this study, we aim to see the relevance of PPI test in diagnosing GERD in patients with extraesophageal symptoms.

Condition	Intervention
Gastroesophageal Reflux Disease	Drug: Proton pump inhibitor (rabeprazole)

Study Type:	Interventional
Study Design:	Diagnostic, Open Label, Parallel Assignment
Official Title:	Clinical Usefulness of Proton Pump Inhibitor Test for Identifying Gastroesophageal Reflux Disease in Patients With Extraesophageal Symptoms

Resource links provided by NLM:

MedlinePlus related topics: GERD

Drug Information available for: E 3810

U.S. FDA Resources

Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:

Symptom responders after PPI trials

Study Start Date:

March 2006

Intervention Details:

Patients receives rabeprazole 20mg AM and 20mg PM for 14 days

Eligibility

Ages Eligible for Study:	20 Years to 75 Years
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

Patients with extraesophageal manifestation symptoms of GERD

Exclusion Criteria:

laryngeal, pharyngeal, liver, lung, renal, or hematological disorders
a history of gastrointestinal surgery, and a history of connective tissue disorders.
patients with duodenal or gastric ulcers as well as other significant lesions, such as gastric cancer, esophageal cancer, or subepithelial tumors more than 1 cm observed on the upper endoscopy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00539786

Contacts

Contact: Tae ggon Kim

+82-2-3410-2975

tggo.kim@samsung.com

Locations

Korea, Republic of, Gangnam-gu
Samsung Medical Center, Sungkyunkwan University School of Medicine	Recruiting
Seoul, Gangnam-gu, Korea, Republic of, 135-710
Contact: Poong Lyul Rhee, M.D., Ph.D +82-2-3410-3409 plrhee@skku.edu
Principal Investigator: Poong-Lyul Rhee, M.D., Ph.D.

Sponsors and Collaborators

Samsung Medical Center

Investigators

Principal Investigator:

Poong-Lyul Rhee, MD. Ph.D

Samsung Medical Center, Sungkyunkwan University School of Medicine

More Information

No publications provided

Study ID Numbers:	2006-03-071
Study First Received:	October 3, 2007
Last Updated:	October 4, 2007
ClinicalTrials.gov Identifier:	NCT00539786 History of Changes
Health Authority:	Korea: Food and Drug Administration

Keywords provided by Samsung Medical Center:

Patients with extraesophageal manifestation of gastroesophageal reflux dsiease

Additional relevant MeSH terms:

Molecular Mechanisms of Pharmacological Action
Gastrointestinal Diseases
Gastrointestinal Agents
Enzyme Inhibitors
Gastroesophageal Reflux
Pharmacologic Actions
Esophageal Motility Disorders

Deglutition Disorders
Digestive System Diseases
Proton Pump Inhibitors
Therapeutic Uses
Anti-Ulcer Agents
Esophageal Diseases
Rabeprazole

ClinicalTrials.gov processed this record on February 08, 2010