Complex Problem Solving Training in Schizophrenic Patients - Full Text View

Sponsors and Collaborators:	University of Heidelberg German Federal Ministry of Education and Research
Information provided by:	University of Heidelberg
ClinicalTrials.gov Identifier:	NCT00507988

Purpose

The primary purpose of the study is to assess whether a planning and problem-solving training is more effective in improving work therapy performance in patients with schizophrenia than traditional training programs addressing basic cognitive functions.

Condition	Intervention
Schizophrenia Schizoaffective Disorder	Behavioral: Complex Problem Solving Training Behavioral: Basic Cognitive Training

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Parallel Assignment, Efficacy Study
Official Title:	Complex Problem Solving Training in Schizophrenic Patients

Resource links provided by NLM:

MedlinePlus related topics: Schizophrenia

U.S. FDA Resources

Further study details as provided by University of Heidelberg:

Primary Outcome Measures:

Functional Capacity as assessed by Osnabrücker Arbeitsfähigkeitsprofil "learning ability" subscale [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Functional Capacity as assessed by the Osnabrücker-Arbeitsfähigkeitsprofil summary score [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
BADS Zoo Map Score (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
Planungstest (Tower of London) Summary Score (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
Plan-A-Day S Solution Time (Neuropsychological Test) [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Enrollment:	91
Study Start Date:	August 2007
Study Completion Date:	February 2009
Primary Completion Date:	February 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
A: Experimental Complex Problem Solving Training	Behavioral: Complex Problem Solving Training 10 sessions of 45 minutes complex problem solving training over 3 weeks (including 30 minutes of computerized planning and problem-solving training with Plan-A-Day and 15 minutes group session for transfer to everyday situations)
B: Active Comparator Basic Cognitive Training	Behavioral: Basic Cognitive Training 10 sessions over 3 weeks of 45 min basic cognitive training (including 45 min computerized training of attention, processing speed, memory)

Detailed Description:

In patients with schizophrenia, cognitive deficits often lead to an impairment in daily life. This observation has led to the development of cognitive training packages aiming a improving these deficits. However, it is far from clear which level of cognitive functioning provides the best target for cognitive interventions. Traditionally, training has aimed a basic cognitive functions like attention and memory. In the present study we aim at a higher-level of function, namely planning and problem-solving skills, which are trained using the software package Plan-A-Day. The primary hypothesis is that complex problem solving training improved functional capacity more than traditional training programs addressing basic cognitive function.

Eligibility

Ages Eligible for Study:	18 Years to 45 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients with schizophrenic or schizoaffective Disorder (DSM IV)
Remitted positive symptoms (PANSS positive all ≤ 4), clinical stability
Native German speaker
Verbal IQ > 80
Visual acuity normal or corrected to normal

Exclusion Criteria:

Concurrent Axis-I disorder
Drug abuse during last 2 months
Neurological or medical conditions potentially affecting cognition

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00507988

Locations

Germany
SRH Klinikum Karlsbad-Langensteinbach
Karlsbad, Germany, 76307

Sponsors and Collaborators

University of Heidelberg

German Federal Ministry of Education and Research

Investigators

Principal Investigator:

Matthias Weisbrod, MD

SRH Klinikum Karlsbad-Langensteinbach, Department of Psychiatry

More Information

No publications provided

Responsible Party:	University Hospital Heidelberg ( Irmtraut Gürkan )
Study ID Numbers:	01GW0630
Study First Received:	July 25, 2007
Last Updated:	May 14, 2009
ClinicalTrials.gov Identifier:	NCT00507988 History of Changes
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Heidelberg:

Cognitive Training
Complex Problem Solving
Goal Management
Planning

Study placed in the following topic categories:

Schizophrenia
Methamphetamine
Mental Disorders

Amphetamine
Psychotic Disorders
Schizophrenia and Disorders with Psychotic Features

Additional relevant MeSH terms:

Schizophrenia
Mental Disorders
Psychotic Disorders
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on July 02, 2009