Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2013 by University of Erlangen-Nürnberg Medical School
Sponsor:
Collaborator:
German Research Foundation
Information provided by (Responsible Party):
University of Erlangen-Nürnberg Medical School
ClinicalTrials.gov Identifier:
NCT00494923
First received: June 29, 2007
Last updated: December 11, 2013
Last verified: December 2013
  Purpose

The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991. The primary aim is the evaluation of diagnostic and prognostic validity of morphometrical, sensory and hemodynamical diagnostic procedures. No therapeutic studies are performed.


Condition
Primary Open Angle Glaucoma
Secondary Open Angle Glaucoma
Ocular Hypertension

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Glaucoma Including Pseudoexfoliation Syndrome (SFB 539)

Resource links provided by NLM:


Further study details as provided by University of Erlangen-Nürnberg Medical School:

Primary Outcome Measures:
  • Time to Disease Progression [ Time Frame: up to 20 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

whole blood


Estimated Enrollment: 2500
Study Start Date: January 1999
Estimated Study Completion Date: December 2020
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Detailed Description:

Purpose: Detection of onset and progression of structural and functional damage due to glaucoma. Determination of rate and amount of progressive change due to glaucoma. Characterisation of the relationship between structural and functional change over time. Evaluation of predictive factors for the development and progression of glaucoma.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

primary care clinic

Criteria

Participants:

  • Patients: Primary open angle glaucoma, secondary open angle glaucoma due to PEX or MDS, glaucoma suspects including ocular hypertension
  • Healthy volunteers (for cross sectional analysis only)

Inclusion Criteria:

  • Open anterior chamber angle
  • Best corrected visual acuity 0.7 or better
  • Age between 18 and 65 years

Exclusion Criteria:

  • Any eye disease other than glaucoma
  • Systemic diseases with potentially ocular involvement (e.g., diabetes mellitus)
  • Myopic or hyperopic refractive error exceeding 8.0 diopters
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00494923

Contacts
Contact: Anselm G Juenemann, Prof. **49-9131-8533001 anselm.juenemann@uk-erlangen.de

Locations
Germany
University Eye Hospital Recruiting
Erlangen, Germany, 91054
Contact: Robert Laemmer, MD    **49-9131-8533001    robert.laemmer@uk-erlangen.de   
Principal Investigator: Christian Y Mardin, Prof.         
Principal Investigator: Folkert K Horn, PhD         
Principal Investigator: Georg Michelson, Prof.         
Sponsors and Collaborators
University of Erlangen-Nürnberg Medical School
German Research Foundation
Investigators
Study Chair: Anselm G Juenemann, Prof. University Erlangen-Nuremberg
  More Information

Publications:

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University of Erlangen-Nürnberg Medical School
ClinicalTrials.gov Identifier: NCT00494923     History of Changes
Other Study ID Numbers: DFG-SFB539-R
Study First Received: June 29, 2007
Last Updated: December 11, 2013
Health Authority: Germany: Ethics Commission

Additional relevant MeSH terms:
Glaucoma
Glaucoma, Open-Angle
Hypertension
Ocular Hypertension
Exfoliation Syndrome
Eye Diseases
Vascular Diseases
Cardiovascular Diseases
Iris Diseases
Uveal Diseases

ClinicalTrials.gov processed this record on August 26, 2014