Respiratory Muscle Strength in Bronchiectasis: Repeatability and Reliability

This study has been completed.
Sponsor:
Information provided by:
University of Ulster
ClinicalTrials.gov Identifier:
NCT00487149
First received: June 13, 2007
Last updated: January 13, 2009
Last verified: January 2009
  Purpose

Respiratory muscle strength is used as an outcome measure in intervention studies. There are reference values for respiratory muscle strength in 'healthy' people but not in those with bronchiectasis disease. The aim of this study is to investigate the reliability of respiratory muscle strength measurements and identify reference values for those with stable moderate to severe bronchiectasis disease.


Condition
Healthy
Bronchiectasis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by University of Ulster:

Enrollment: 40
Study Start Date: October 2005
Study Completion Date: July 2008
Detailed Description:

Twenty 'healthy' participants and 20 participants with moderate to severe bronchiectasis in a stable state were recruited. Three readings for pulmonary function (FEV1); and respiratory muscle strength (PImax;PEmax) were taken on two occasions 10-14 days apart according to a standardised protocol.

A standard protocol and instructions for all measurements of respiratory strength were used. Measurements were made at the same time of day and with no change in medication. Before the subject undertook the respiratory muscle strength tests the assessor provided verbal explanations and demonstration of the procedure. The subject then had a practice run before values were recorded. Values were reported as positive numbers.

Measurements were obtained by one of three assessors. Pretraining ensured that all assessors followed standardised methodology.

Pulmonary function measures were conducted according to the ATS standards (ATS, 2002). The FEV1 percentage predicted value was reported as the ECCS scale. FEV1 had to remain within 10% to eliminate the possibility of a pulmonary exacerbation.

Respiratory muscle strength measurements were conducted using a handheld mouth pressure meter, a one way inspiratory or expiratory valve, a single use bacterial filter, nose clips and a standard flanged mouthpiece (Micro Medical Ltd UK). The pressure gauge was calibrated with a small air leak (greater than 1mm in diameter) to reduce use of the buccal muscles. A hand held mouth pressure machine computed average pressures in cmH2O sustained over two seconds and a microprocessor displayed a digital result.PImax was measured near residual volume after maximal expiration. PEmax was measured near total lung capacity after a maximal inspiration. There was a minute's rest between each manoeuvre. Verbal encouragement was given to each participant to obtain maximal effort. Three technically acceptable readings for inspiratory and expiratory pressure measured were recorded.

All participants gave written informed consent.

  Eligibility

Ages Eligible for Study:   40 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • All participants:over 40 years of age,non smokers,able to perform lung function tests and available for a repeat measure 10-14 days later.
  • Specific inclusion criteria for healthy participants:no known respiratory or cardiac condition and no prescription antibiotics for a chest complaint.
  • Specific inclusion criteria for bronchiectasis group:

    • Diagnosis of bronchiectasis by CT scan;
    • Moderate to severe disease (FEV1 < 60% predicted);
    • In a stable state i.e. no administration of oral or intravenous antibiotics in preceding 3 weeks;
    • No change in medication such as bronchodilators, oxygen, long term prophylactic antibiotics or steroids in the 3 weeks preceding the study.

Exclusion Criteria:

  • Any co-morbid condition that could influence muscle strength or if participants live greater than 50 miles from the hospital.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00487149

Locations
United Kingdom
Belfast City Hospital
Belfast, Northern Ireland, United Kingdom, BT9 7AB
Sponsors and Collaborators
University of Ulster
Investigators
Principal Investigator: Fidelma Moran, BSc(Hons) University of Ulster
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00487149     History of Changes
Other Study ID Numbers: 1233R0203
Study First Received: June 13, 2007
Last Updated: January 13, 2009
Health Authority: United Kingdom: Department of Health

Keywords provided by University of Ulster:
Repeatability
Respiratory Muscle Strength

Additional relevant MeSH terms:
Bronchiectasis
Bronchial Diseases
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on October 23, 2014