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Insulin Resistance : Heart Failure

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2007 by University of Dundee.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Dundee
ClinicalTrials.gov Identifier:
NCT00486967
First received: June 13, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted
  Purpose

Whether insulin resistance common among Chronic Heart Failure (CHF) patients in Tayside and identify factors associated with insulin resistance in CHF.

We also want to identify mechanism for the impaired exercise capacity and reduced peak VO2 in CHF


Condition
Congestive Heart Failure
Heart Failure

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Insulin Resistance: A New Target in Heart Failure

Resource links provided by NLM:


Further study details as provided by University of Dundee:

Study Start Date: August 2006
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   30 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • One hundred patients with Left ventricular Ejection Friction (LVEF) <35% in NYHA class I II III or IV; aged 30-90, attending the CHF clinic will be studied
  • Diagnosis of CHF will be based on medical history of exertional dyspneoa, muscle fatigue and/or fluid retention and diminished LVEF (LVEF<35%)
  • The diagnosis of ischemic heart disease will be based on documentation of previous myocardial infarction, coronary artery bypass surgery or pathologic findings on coronary angiography. Idiopathic dilated cardiomyopathy will be diagnosed in the absence of a specific etiology for left ventricular dysfunction and on the basis of normal coronary arteries
  • All patients should be stable with their treatment and no change in their treatment regimen for > 6 weeks before the study
  • Patients with CHF due to coronary artery disease are more likely to have abnormalities in glucose metabolism than are patients with CHF due to idiopathic dilated cardiomyopathy. Therefore, we also plan to study a control group [n=50] of age and sex and BMI matched patients divided into 2 groups 25 with coronary artery disease without heart failure and 25 healthy control. These patients will be identified from the Cardiology Clinics

Exclusion Criteria:

  • Patients with decompensated CHF with signs of congestion
  • Since the objective of the study is to assess prevalence of insulin resistance in CHF and not CHF secondary to other diseases like diabetes mellitus (DM), patients suffering from DM will be excluded
  • Individual found during study cognitively impaired rendering them incapable to take part
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00486967

Contacts
Contact: Matlooba A ALZadjali, BSc, MD, MPH 0044(0)1382 660111 ext 33176 m.alzadjali@dundee.ac.uk

Locations
United Kingdom
University of Dundee Recruiting
Dundee, United Kingdom, DD1 9SY
Contact: James Houston    0044(0)1382384664    j.z.houston@dundee.ac.uk   
Sub-Investigator: MATLOOBA A ALZadjali, BSC,MD,MPH         
Sponsors and Collaborators
University of Dundee
Investigators
Principal Investigator: Chim C Lang, MD, FRCP University of Dundee, Scotland, UK
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00486967     History of Changes
Other Study ID Numbers: MAT001
Study First Received: June 13, 2007
Last Updated: June 13, 2007
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by University of Dundee:
Insulin resistance, heart failure, congestive heart failure,
Peak VO2, Endothelial Function, Leptin, TNF.

Additional relevant MeSH terms:
Heart Failure
Insulin Resistance
Cardiovascular Diseases
Glucose Metabolism Disorders
Heart Diseases
Hyperinsulinism
Metabolic Diseases
Insulin
Hypoglycemic Agents
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on November 27, 2014