Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00476372
First received: May 21, 2007
Last updated: January 11, 2013
Last verified: January 2013
  Purpose

Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the type and severity of cognitive impairment. This discrepancy can in part be caused by the lack of distinction between patients with different motor symptoms and disease severity.

Objective: To identify the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the severity and type of cognitive dysfunction in patients with idiopathic PD categorized according to motor symptoms and disease severity.

Methods: the population of patients with PD in the old county of Aarhus is described on the background of medical records, and stratified in accordance to age, sex and cardinal symptoms. Through proportional allocation a sample of a minimum of 50 patients with PD is drawn from the population. The patients and 30 healthy matched controls will undergo comprehensive neuropsychological assessment including tests of language, memory, executive function, and visuospatial function. Furthermore, all participants will be screened for depression (Geriatric Depression Scale) and psychiatric symptoms (Neuropsychiatric Inventory and Symptom Checklist). The patients will be categorized in accordance with their motor symptoms via cluster analysis for the purpose of analyzing the effect of psychiatric symptoms, depression, and age of disease onset, disease duration, and medication on cognition.


Condition
Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms -the Relation Between Cognitive Deficits and Comorbid Psychiatric Disorders, Medication, and Age at Disease Onset

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • cognitive measures [ Time Frame: 1 hour ] [ Designated as safety issue: No ]

Enrollment: 107
Study Start Date: August 2007
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
Parkinson's disease
Pt with parkinsons disease

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

77 patients with PD and 30 healthy control participants

Criteria

Inclusion Criteria:

  • Idiopathic Parkinson's in accordance to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria,
  • Born and raised in Denmark ,
  • >50 years

Exclusion Criteria:

  • Cerebrovascular disease,
  • Dementia not caused by Parkinson's Disease,
  • Metabolism anomaly,
  • Abuse of drugs, medication or alcohol,
  • History of head injuries,
  • Severe psychiatric disorder, excluding depression,
  • Resident outside the region of Aarhus h) DBS -
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00476372

Locations
Denmark
Aarhus Universitetshospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Investigators
Study Chair: Karen Østergaard, neurologist Aarhus Universitetshospital
Study Chair: Lars Larsen, MSc, PhD, Associate Professor The Institute of Psychology
  More Information

No publications provided

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00476372     History of Changes
Other Study ID Numbers: UAarhus
Study First Received: May 21, 2007
Last Updated: January 11, 2013
Health Authority: Denmark: The Ministry of the Interior and Health

Keywords provided by University of Aarhus:
neuropsychology
cognitive impairment
motor disorder
parkinson's disease

Additional relevant MeSH terms:
Parkinson Disease
Cognition Disorders
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on October 01, 2014