Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2009 by Radboud University.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Radboud University
ClinicalTrials.gov Identifier:
NCT00441753
First received: February 28, 2007
Last updated: February 5, 2009
Last verified: February 2009
  Purpose

Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.


Condition
Cardiac Arrest
Post-Anoxic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Resource links provided by NLM:


Further study details as provided by Radboud University:

Estimated Enrollment: 10
Study Start Date: September 2006
  Eligibility

Ages Eligible for Study:   18 Years to 95 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients after cardiac arrest, comatose and treated with therapeutic hypothermia

Criteria

Inclusion Criteria:

  • adult patients
  • GCS after return of circulation < 7
  • Induced mild hypothermia for 24 hours
  • primary rhythm ventricular fibrillation

Exclusion Criteria:

  • Thrombolysis
  • Cardiogenic shock with expected survival < 24 hrs
  • Pregnancy
  • No informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00441753

Contacts
Contact: Cornelia Hoedemaekers, MD PhD 00.31.24.3617273 C.Hoedemaekers@ic.umcn.nl

Locations
Netherlands
Radboud University Nijmegen Medical Centre Recruiting
Nijmegen, Netherlands, 6500 HB
Contact: Cornelia Hoedemaekers, MD PhD    00.31.24.3617273    C.Hoedemaekers@ic.umcn.nl   
Sub-Investigator: Koen Simons, MD         
Sponsors and Collaborators
Radboud University
Investigators
Principal Investigator: Cornelia Hoedemaekers, MD PhD Radboud University
Study Director: Johannes van der Hoeven, MD PhD Radboud University
  More Information

No publications provided

Responsible Party: Radboud UNiversity Nijmegen Medical Centre
ClinicalTrials.gov Identifier: NCT00441753     History of Changes
Other Study ID Numbers: KSCH0601
Study First Received: February 28, 2007
Last Updated: February 5, 2009
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Additional relevant MeSH terms:
Hypoxia, Brain
Heart Arrest
Hypothermia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Heart Diseases
Cardiovascular Diseases
Body Temperature Changes
Signs and Symptoms

ClinicalTrials.gov processed this record on July 20, 2014