Inclusion Criteria:

• Histologically confirmed, previously untreated Grade I-II follicular B-cell non-Hodgkin's lymphoma (stage I, II, III and IV). Patients may have received radiation therapy to one lymph node region; Stage I or II patients must have relapsed after prior radiation therapy to be eligible;
• Patients with any FLIPI score may participate. Patients with FLIPI scores 3-5 may be enrolled with asymptomatic disease, or without worsening disease or disease related-symptoms; however patients with FLIPI scores of 0-2 must have evidence of worsening disease;
• ECOG performance status 0-1;
• Measurable disease;

• Adequate hematological function as indicated by:

  • Absolute neutrophil count (ANC) >1,000/µL; +Hemoglobin >8 g/dL (It is acceptable to transfuse PRBC to achieve this criterion);
  • Platelet count >50 x 109/L.

• Adequate hepatic and renal function as indicated by:

  • Serum creatinine ≤2.0 mg/dL;
  • Serum albumin ≥2.5 g/dL;
  • Total bilirubin ≤1.5 x upper limit of normal (ULN);
  • Serum AST and ALT ≤1.5 x ULN.
• Able to swallow and retain oral medication

Exclusion Criteria:

• Patients who have severe lymphoma-related symptoms requiring a rapid response to therapy (e.g., requirement for cytoreduction due to advanced disease or organ compromise, respiratory compromise because of large effusions or airway obstruction, bowel obstruction, ureteral obstruction, and chylous ascites);
• Active symptomatic fungal, bacterial and/or viral infection including, but not limited to active HIV or viral hepatitis (A, B or C);
• History of hepatitis B infection;
• Any B-cell, T-cell or transformed lymphoma other than histologically confirmed follicular non-Hodgkin's lymphoma;
• Central nervous system (CNS) lymphoma, CNS or leptomeningeal involvement by lymphoma (treated or in remission), HIV-related lymphoma, or patients with symptoms suggesting HIV infection;