Long-Term IOP Fluctuation and VF Progression After Triple Procedure - Full Text View

Sponsor:	Yonsei University
Information provided by:	Yonsei University
ClinicalTrials.gov Identifier:	NCT00428740

Purpose

Long-term intraocular pressure (IOP) fluctuation may be significantly associated with the progression of glaucomatous visual field loss, even in patients kept always low IOP after triple procedure, an effective approach for patients with coexisting glaucoma and visually significant cataracts.

Condition
Glaucoma Filtering Surgery Intraocular Pressure

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Retrospective Study
Official Title:	Long-Term Intraocular Pressure Fluctuation and Visual Field Progression in Glaucoma Patients With Low Intraocular Pressure After Triple Procedure

Resource links provided by NLM:

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

U.S. FDA Resources

Further study details as provided by Yonsei University:

Estimated Enrollment:	300
Study Start Date:	October 2005
Estimated Study Completion Date:	December 2005

Detailed Description:

Previous studies reported that lowering intraocular pressure (IOP) slowed the advancement of visual field damage in glaucoma patients. However, even if the IOP can been substantially lowered, reduction of mean and peak IOP does not always prevent visual field progression.We believe that the long-term IOP fluctuation may play a significant role in visual field deterioration in those patients.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Underwent triple procedure
At leas 3 years of follow-up after surgery
IOP <18mmHg at each postoperative visit
A minimum of 5 visual field examinations
A reference visual field defect score of 16 or less
Good reliability indices of visual field

Exclusion Criteria:

Any other significant ocular diseases or intraocular surgical histories,
Diseases that may affect visual field or diabetes

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00428740

Locations

Korea, Republic of
Yonsei University College of Medicine
Seoul, Korea, Republic of, 135-720

Sponsors and Collaborators

Yonsei University

Investigators

Principal Investigator:

Gong Je Seong, MD, PhD

Yondgong Severance Hospital, Yonsei University College of Medicine

More Information

No publications provided by Yonsei University

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Hong S, Seong GJ, Hong YJ. Long-term intraocular pressure fluctuation and progressive visual field deterioration in patients with glaucoma and low intraocular pressures after a triple procedure. Arch Ophthalmol. 2007 Aug;125(8):1010-3.

Study ID Numbers:	3-2006-0388
Study First Received:	January 29, 2007
Last Updated:	January 29, 2007
ClinicalTrials.gov Identifier:	NCT00428740 History of Changes
Health Authority:	South Korea: Institutional Review Board

Additional relevant MeSH terms:

Glaucoma
Eye Diseases
Ocular Hypertension

ClinicalTrials.gov processed this record on February 08, 2010