Effects of Roaccutane on Ca, P, PTH and Vitamin D Metabolites in the Treatment of Sever Acne

This study has been completed.

First Received: December 27, 2006 Last Updated: January 22, 2008 History of Changes

Sponsored by:	Shaheed Beheshti Medical University
Information provided by:	Shaheed Beheshti Medical University
ClinicalTrials.gov Identifier:	NCT00416585

Purpose

serum levels Ca, P, PTH and vitamin D metabolites before and after treatment with isotretinoin for sever acne

Condition	Intervention	Phase
Acne	Drug: isotretinoin (Roaccutane)	Phase I

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Dose Comparison, Single Group Assignment, Safety/Efficacy Study
Official Title:	Effects of Roaccutane on Ca, P, PTH and Vitamin D Metabolites in the Treatment

Resource links provided by NLM:

MedlinePlus related topics: Acne X-Rays

Drug Information available for: Vitamin D Isotretinoin

U.S. FDA Resources

Further study details as provided by Shaheed Beheshti Medical University:

Primary Outcome Measures:

serum levels of Ca, P, PTH and vitamin D metabolites and lateral chest x-ray before the treatment

Secondary Outcome Measures:

serum levels of Ca, P, PTH and vitamin D metabolites and lateral chest x-ray after the treatment

Estimated Enrollment:	30
Study Start Date:	October 2005
Estimated Study Completion Date:	November 2006

Detailed Description:

few studies has been done of serum levels Ca, P, PTH and vitamin D metabolites in patients receiving isotretinoin .In this study we measured serum levels Ca, P, PTH and vitamin D metabolites before and after treatment with isotretinoin for sever acne in 30 patients . the patients had no kown skeletal, endocrine ,renal and gastrointestinal disorders.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

sever acne

Exclusion Criteria:

renal disorders
gastrointestinal disorders
skeletal disorders
endocrine disorders
drugs such as glucocorticoids , thiazide diuretics, mineral multivitamins, anti acids, tetracyclines

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00416585

Locations

Iran, Islamic Republic of
Shaheed Beheshti Medical University, Skin research center
Tehran, Iran, Islamic Republic of, 198994148

Sponsors and Collaborators

Shaheed Beheshti Medical University

Investigators

Study Chair:	parviz toossi, md	Skin Research Center
Principal Investigator:	Hamideh Moravvej, md	Skin Research Center
Principal Investigator:	Nahid Mohtasham, md	Skin Research Center

More Information

No publications provided

Study ID Numbers:	src-hmnm-1385
Study First Received:	December 27, 2006
Last Updated:	January 22, 2008
ClinicalTrials.gov Identifier:	NCT00416585 History of Changes
Health Authority:	Iran: Ministry of Health

Keywords provided by Shaheed Beheshti Medical University:

acne
isotretinoin
calcium. vitamin D

Study placed in the following topic categories:

Facial Dermatoses
Skin Diseases
Facies
Bone Density Conservation Agents
Trace Elements
Sebaceous Gland Diseases
Acne Vulgaris

Exanthema
Calcium, Dietary
Vitamin D
Vitamins
Isotretinoin
Micronutrients

Additional relevant MeSH terms:

Facial Dermatoses
Skin Diseases
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents
Sebaceous Gland Diseases
Acne Vulgaris
Pharmacologic Actions

Vitamin D
Acneiform Eruptions
Therapeutic Uses
Vitamins
Isotretinoin
Micronutrients
Dermatologic Agents

ClinicalTrials.gov processed this record on July 02, 2009