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Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

This study has been completed.
Sponsor:
Information provided by:
Bispebjerg Hospital
ClinicalTrials.gov Identifier:
NCT00404469
First received: November 27, 2006
Last updated: May 21, 2008
Last verified: May 2008
History of Changes
  Purpose

We will investigate the effect of peritendinous corticosteroid injections, eccentric training and heavy resistance training in male patellar tendinopathy patients. The purpose is to compare the clinical effect of these three treatments in a randomised controlled trial. Also we wish to investigate the treatment mechanisms responsible for the effectiveness of the three treatments.


Condition Intervention
Patellar Tendinopathy / Jumpers Knee
 Procedure: peritendinous corticosteroid injections
Procedure: eccentric decline squat training
Procedure: heavy slow resistance training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

Resource links provided by NLM:

MedlinePlus related topics: Steroids Tendinitis
U.S. FDA Resources

Further study details as provided by Bispebjerg Hospital:

Enrollment: 39
Study Start Date: March 2006
Study Completion Date: November 2007
Arms Assigned Interventions
Active Comparator: CORT
Peritendinous corticosteroid injections at 0 and 4 weeks. 12 weeks total
 Procedure: peritendinous corticosteroid injections
1 ml of40mg/ml methylprednisolone acetate at 0 and 4 weeks. 2 week observational
Experimental: ECC
12 weeks of eccentric unilateral decline squats
 Procedure: eccentric decline squat training
eccentric decline unilateral squats performed twice daily. for 12 weeks
Experimental: HSR
Heavy slow resistance training. 3/week. 12 weeks
 Procedure: heavy slow resistance training
Heavy slow resistance training for knee extensors. 3/week. total of 12 weeks

Detailed Description:

3 interventions groups as described above (n=13 in each group) 12 weeks intervention period. Clinical assessments before and after intervention: VAS, VISA, Tendon thickness, Doppler us activity.

Before and after intervention tendon biopsies will be taken and analyzed for crosslinks and fibril diameter. Also tendon mechanical properties will be measured. Tendon and muscle structural properties will be measured with MRI.

Treatment satisfaction will be stated after intervention period.

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical patellar tendinopathy pain.
  • Tendon swelling
  • Hypoechoic
  • Doppler activity in tendon

Exclusion Criteria:

  • Previous knee surgery
  • diabetes
  • arthritis
  • previous steroid injections
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00404469

Locations
Denmark
Institute of Sports Medicine Copenhagen. Dept 8 1st floor. Bispebjerg Hospital
Copenhagen, Denmark, 2400
Sponsors and Collaborators
Bispebjerg Hospital
Investigators
Principal Investigator: Mads Kongsgaard, PhD., MSc. Institute of Sports Medicine, Copenhagen
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00404469     History of Changes
Other Study ID Numbers: Patellar tendinopathy
Study First Received: November 27, 2006
Last Updated: May 21, 2008
Health Authority: Denmark: Ethics Committee

Additional relevant MeSH terms:
Tendinopathy
Muscular Diseases
Musculoskeletal Diseases
Tendon Injuries
Wounds and Injuries

ClinicalTrials.gov processed this record on May 16, 2013