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| Sponsor: | Montreal Heart Institute |
|---|---|
| Collaborator: |
AstraZeneca |
| Information provided by: | Montreal Heart Institute |
| ClinicalTrials.gov Identifier: | NCT00400582 |
Purpose
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
| Condition | Intervention | Phase |
|---|---|---|
|
Heart Failure |
Drug: Candesartan up to 32 mg daily |
Phase IV |
| Study Type: | Interventional |
| Study Design: | Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacodynamics Study |
| Official Title: | Effect of ACE Inhibitor Plus High Dose Candesartan on BNP and Inflammation in Patients With LV Dysfunction: Impact of Renin-Angiotensin-Aldosterone System Genetic Polymorphisms |
| Estimated Enrollment: | 300 |
| Study Start Date: | November 2006 |
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Principal Inclusion Criteria:
Principal Exclusion Criteria:
Contacts and Locations| Contact: Lucette Whittom, RN, BSc | 514-376-3330 ext 3931 | lucette.whittom@icm-mhi.org |
| Canada, Quebec | |
| Montreal Heart Institute | Recruiting |
| Montreal, Quebec, Canada, H1T 1C8 | |
| Contact: Lucette Whittom, Rn, BSc 376-3330 ext 3931 lucette.whittom@icm-mhi.org | |
| Principal Investigator: | Michel White, MD | Montreal Heart Institute |
| Principal Investigator: | Simon de Denus, B. Pharm, MSc | Montreal Heart Institute/ Faculty of Pharmacy, University of Montreal |
More Information
| Responsible Party: | Montreal Heart Institute ( Michel White ) |
| Study ID Numbers: | MHI 06-890, D2454L00003 |
| Study First Received: | November 15, 2006 |
| Last Updated: | July 9, 2009 |
| ClinicalTrials.gov Identifier: | NCT00400582 History of Changes |
| Health Authority: | Canada: Health Canada |
|
Heart failure Gene polymorphism Candesartan |
ACE inhibitors BNP Pharmacogenomics |
|
Heart Failure Heart Diseases Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions |
Protease Inhibitors Angiotensin II Type 1 Receptor Blockers Candesartan cilexetil Therapeutic Uses Candesartan Angiotensin-Converting Enzyme Inhibitors Cardiovascular Diseases |