Scientific Evaluation of Peer Education and STD Treatment to Reduce the Spread of HIV in Zimbabwe

This study has been completed.
Sponsor:
Collaborator:
Biomedical Research and Training Institute
Information provided by:
Imperial College London
ClinicalTrials.gov Identifier:
NCT00390949
First received: October 20, 2006
Last updated: January 9, 2007
Last verified: October 2006
  Purpose

The purpose of this study is to determine whether community-based peer education and condom distribution combined with improved treatment of sexually transmitted infections are effective in reducing the spread of HIV infection in a sub-Saharan African population


Condition Intervention
HIV Infections
Behavioral: Peer education among commercial sex workers and clients
Behavioral: Condom distribution and promotion
Procedure: Syndromic treatment of sexually transmitted infections
Procedure: Systemic counselling for STI patients

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: a Cluster-Randomised Trial in Eastern Zimbabwe

Resource links provided by NLM:


Further study details as provided by Imperial College London:

Primary Outcome Measures:
  • HIV incidence at the community level

Secondary Outcome Measures:
  • Self-reported genital ulcers
  • Self-reported urethral or genital discharge
  • Sexually transmitted infection treatment effectiveness (self-reported cessation of symptoms)
  • Sexual behaviour change (sexual debut, sexual partner change, non-regular partners, unprotected sex with regular and casual partners)
  • Health-seeking behaviour change
  • HIV/AIDS knowledge

Study Start Date: July 1998
Estimated Study Completion Date: February 2003
  Show Detailed Description

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • All members of study communities
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00390949

Locations
Zimbabwe
Biomedical Research and Training Institute
Harare, Zimbabwe
Sponsors and Collaborators
Imperial College London
Biomedical Research and Training Institute
Investigators
Principal Investigator: Simon Gregson, DPhil Imperial College London
Principal Investigator: Stephen Chandiwana, PhD Biomedical Research and Training Institute
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT00390949     History of Changes
Other Study ID Numbers: PC3239_DFID
Study First Received: October 20, 2006
Last Updated: January 9, 2007
Health Authority: United Kingdom: Research Ethics Committee

Keywords provided by Imperial College London:
HIV prevention
Zimbabwe
Core groups
Peer education
Syndromic management
Commercial sex workers
Condom distribution
HIV Seronegativity

Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases

ClinicalTrials.gov processed this record on September 29, 2014